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首页> 外文期刊>Journal of Medical Virology >Human papillomavirus infection in lung and esophageal cancers: analysis of 485 Asian cases.
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Human papillomavirus infection in lung and esophageal cancers: analysis of 485 Asian cases.

机译：肺癌和食道癌中人乳头瘤病毒感染：485例亚洲病例分析。

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摘要

The role of human papillomavirus (HPV) in the development of lung and esophageal cancer remains inconclusive, which is in contrast to the established role HPV plays in the development of uterine cervical cancer. One of the reasons for this is the difference among reported HPV infection rates in these cancers. An analysis of 485 lung and esophageal cancers (176 lung squamous cell carcinoma, 128 lung adenocarcinoma, 181 esophageal carcinoma) in eight institutions in Asia (Tokyo, Kochi, Kagoshima, and Okinawa, Japan; Seoul and Daegu, Korea; Changhua, Republic of China (Taiwan); Singapore, Singapore) was carried out in order to clarify infection rates with HPV. Samples were examined in one laboratory of the Department of Pathology, the University of Tokyo, Japan in order to avoid inter-laboratory variation using a combination of polymerase chain reaction and in situ hybridization (ISH). HPV was found in 6.3%, 7%, and 9.4% of patients with lung squamous cell carcinoma, lung adenocarcinoma, and esophageal cancer, respectively. Among the geographic areas surveyed, Kagoshima exhibited a significantly higher prevalence of HPV infection in cases of esophageal carcinoma (24.1%). There was no geographical difference in the infection rates of HPV in lung carcinomas. Subtype-specific ISH was also performed, which identified the high-risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV.
机译：人类乳头瘤病毒（HPV）在肺癌和食道癌发展中的作用尚无定论，这与HPV在子宫宫颈癌的发展中已确立的作用形成鲜明对比。原因之一是这些癌症中报告的HPV感染率之间存在差异。在亚洲的八个机构（东京，高知，鹿儿岛和冲绳，日本首尔和大邱，韩国昌化，中华民国）对485例肺癌和食管癌（176例肺鳞癌，128例肺腺癌，181例食管癌）进行了分析。为了阐明HPV的感染率，进行了中国（台湾）;新加坡，新加坡）。为了避免使用聚合酶链反应和原位杂交（ISH）的实验室间差异，样品在日本东京大学病理学系的一个实验室中进行了检查。在肺鳞癌，肺腺癌和食管癌患者中分别发现HPV占6.3％，7％和9.4％。在所调查的地理区域中，鹿儿岛市在食管癌病例中表现出明显更高的HPV感染率（24.1％）。肺癌中HPV的感染率没有地理差异。还进行了亚型特异性ISH，这在大多数（75.7％）的HPV阳性的肺癌和食道癌患者中鉴定出高危型HPV 16/18。

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