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首页> 外文期刊>Journal of Medical Virology >Low IgG avidity and ultrasound fetal abnormality predict congenital cytomegalovirus infection
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Low IgG avidity and ultrasound fetal abnormality predict congenital cytomegalovirus infection

机译：低IgG亲和力和胎儿超声异常可预测先天巨细胞病毒感染

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摘要

Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates. The aim of this study was to assess whether prenatal clinical or laboratory findings in pregnant women who had high risks for primary CMV infection predicted the presence of congenital infection. Fifty pregnant women who had serum CMV IgG and positive or borderline tests for serum CMV IgM were included in this prospective study. Serum IgG avidity was measured, and PCR was conducted for CMV DNA in maternal serum, urine, and uterine cervical secretion. All neonates underwent PCR testing for CMV DNA in the urine for the presence of congenital infection. Risk factors were compared between congenital infection group and group without congenital infection. As a result, nine neonates (18%) were diagnosed as having congenital infection. The frequencies of ultrasound fetal abnormality and positive test for CMV DNA in cervical secretion, CMV IgM titer and IgM/IgG ratio in the congenital infection group were significantly higher than those in the group without congenital infection. Conversely, IgG avidity index in the congenital infection group was significantly lower than that in the group without congenital infection. By multivariate logistic regression analyses, IgG avidity index (Odds ratio 0.91, 95% CI: 0.83-0.99) and ultrasound fetal abnormality (291.22, 2.72-31125.05), were selected independently as significant signs predictive of congenital CMV infection. Among pregnant women with positive or borderline tests for CMV IgM, when they have findings of low serum CMV IgG avidity or ultrasound fetal abnormality, the probability of congenital CMV infection may increase.
机译：巨细胞病毒（CMV）导致先天性感染，受影响的新生儿死亡率和发病率很高。这项研究的目的是评估患有原发性巨细胞病毒感染高风险孕妇的产前临床或实验室检查结果是否预示了先天性感染的存在。这项前瞻性研究包括了50名血清CMV IgG含量为血清CMV IgM阳性或临界试验的孕妇。测量血清IgG的亲和力，并进行PCR检测母体血清，尿液和子宫宫颈分泌物中的CMV DNA。所有新生儿均进行了尿液中CMV DNA的PCR检测，以检查是否存在先天性感染。比较先天性感染组和非先天性感染组的危险因素。结果，有9名新生儿（18％）被诊断患有先天性感染。先天性感染组的胎儿超声检查异常频率和宫颈分泌物CMV DNA阳性检测，CMV IgM效价和IgM / IgG比值明显高于无先天性感染组。相反，先天性感染组的IgG亲和力指数显着低于无先天性感染的组。通过多元逻辑回归分析，分别选择IgG亲和力指数（几率0.91，95％CI：0.83-0.99）和超声胎儿异常（291.22，2.72-31125.05）作为预示先天性巨细胞病毒感染的重要标志。在对CMV IgM进行​​阳性或临界检测的孕妇中，当发现血清CMV IgG亲和力低或胎儿胎儿超声异常时，先天性CMV感染的可能性可能会增加。

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