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首页> 外文期刊>Journal of Medical Virology >Prevalence of hepatitis B virus infection in a highly endemic area of southern China after catch-up immunization
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Prevalence of hepatitis B virus infection in a highly endemic area of southern China after catch-up immunization

机译：追赶免疫后中国南部高流行地区的乙型肝炎病毒感染率

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The Chinese national goals for control of hepatitis B virus (HBV) infection were to achieve a prevalence of HBsAg below 7% for the entire population, and 1% for children under 5-year old, by 2010. To determine whether Guangxi, a multi-minority province with a low socio-economic status and a very high prevalence of HBV, achieved this goal, a seroepidemiological survey of HBV infection was carried out using stratified, random cluster sampling. The results show that the overall prevalence of HBsAg is 9.16% [95% confidence interval (CI)=8.32-10%]. The prevalence in males (10.96%, 95% CI=9.64-12.28%) is significantly higher than in females (7.71%, 95% CI=6.64-8.78%; χ 2=10.5923, P0.05). The prevalence in children under 5-year old is 3.62% (95% CI=0.60-6.64%) and increases with age. The prevalence of HBsAg in non-immunized individuals is significantly higher than in those immunized completely, although not within 24hr of birth (χ 2=31.426, P0.05); a significant difference was found in those below the age of 20 years but not in older persons. Gender, age, immunization history, and familial HBsAg carriers are risk factors for infection. In conclusion, this study indicates that Guangxi has not reached the goal for the control of HBV infection. Catch-up HBV immunization may not protect adults effectively against infection in highly endemic regions.
机译：中国控制乙肝病毒（HBV）感染的国家目标是到2010年使整个人群的HBsAg患病率低于7％，5岁以下儿童的HBsAg患病率低于1％。社会经济地位较低且乙肝病毒感染率很高的少数民族省份已实现了这一目标，我们采用分层随机整群抽样方法对乙肝病毒感染进行了流行病学调查。结果显示，HBsAg的总体患病率为9.16％[95％置信区间（CI）= 8.32-10％]。男性（10.96％，95％CI = 9.64-12.28％）的患病率显着高于女性（7.71％，95％CI = 6.64-8.78％;χ2 = 10.5923，P <0.05）。 5岁以下儿童的患病率为3.62％（95％CI = 0.60-6.64％），并随着年龄的增长而增加。尽管未在出生后24小时内，但未免疫组的HBsAg患病率明显高于完全免疫组（χ2 = 31.426，P <0.05）;在20岁以下的人群中发现了显着差异，但在老年人中却没有。性别，年龄，免疫史和家族性HBsAg携带者是感染的危险因素。总之，这项研究表明广西尚未达到控制HBV感染的目标。在高流行地区，追赶HBV免疫可能无法有效保护成年人免受感染。

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