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首页> 外文期刊>Journal of Medical Virology >Correlation between serum matrix metalloproteinase and antigenemia levels in patients infected with rotavirus
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Correlation between serum matrix metalloproteinase and antigenemia levels in patients infected with rotavirus

机译：轮状病毒感染患者血清基质金属蛋白酶与抗原血症水平的相关性

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摘要

Rotavirus (RV) antigenemia has been reported in patients with gastroenteritis; however, the exact mechanism remains unclear. In order to elucidate the mechanism of RV antigenemia, an association between RV antigenemia and matrix metalloproteinase (MMP) were analyzed. The object of this study was to elucidate the role of MMPs and tissue inhibitors of metalloproteinases (TIMPs) in the pathogenesis of RV antigenemia. Forty children admitted to hospital with RV gastroenteritis were enrolled in this study. Paired serum samples were collected at the time of admission and discharge. Enzyme-linked immunosorbent assays (ELISA) were used to detect serum concentrations of viral antigens, MMP-1, -2, -9, -13, TIMP -1, and -2. Cytokines were measured using flow cytometric beads array. RV antigens were significantly higher in serum collected at the time of admission than discharge (P<0.001). MMP-9 concentrations were significantly higher in serum collected at the time of admission than discharge (P<0.001). MMP-2 concentrations were significantly lower in serum collected at the time of admission than discharge (P<0.001). A weak but a significantly positive association (P=0.034) was observed between RV antigen and MMP-9 in serum collected at the time of admission, and inverse association was observed between RV antigen and MMP-2. In addition, a weak but significantly positive association (P=0.002) was observed between IL-6 and MMP-9. These data suggest that MMPs may contribute to the pathogenesis of RV antigenemia.
机译：胃肠炎患者已有轮状病毒（RV）抗原血症的报道。但是，确切的机制仍不清楚。为了阐明RV抗原血症的机制，分析了RV抗原血症与基质金属蛋白酶（MMP）之间的关联。这项研究的目的是阐明MMPs和金属蛋白酶组织抑制剂（TIMPs）在RV抗原血症的发病机理中的作用。这项研究纳入了40名入院RV肠胃炎的儿童。在入院和出院时收集配对的血清样本。酶联免疫吸附测定（ELISA）用于检测病毒抗原，MMP-1，-2，-9，-13，TIMP -1和-2的血清浓度。使用流式细胞仪微珠阵列测量细胞因子。入院时采集的血清中的RV抗原显着高于出院（P <0.001）。入院时采集的血清中MMP-9浓度显着高于出院（P <0.001）。入院时采集的血清中MMP-2浓度显着低于出院（P <0.001）。入院时血清中RV抗原与MMP-9之间观察到弱但显着的正相关（P = 0.034），RV抗原与MMP-2之间观察到负相关。另外，在IL-6和MMP-9之间观察到弱但显着的正相关（P = 0.002）。这些数据表明MMPs可能有助于RV抗原血症的发病机理。

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