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首页> 外文期刊>Journal of Medical Virology >Case Report: Risk of virus infection after accidental blood inoculation from a multi-infected AIDS patient
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Case Report: Risk of virus infection after accidental blood inoculation from a multi-infected AIDS patient

机译：病例报告：一名多感染艾滋病患者意外接种血液后感染病毒的风险

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摘要

Infections caused by blood-borne viruses such as hepatitis B and C and the human immunodeficiency virus (HIV) are associated commonly with needlestick injuries, especially in a hospital setting. A prospective investigation was conducted on a medical doctor who suffered an accidental needlestick injury during blood collection from a patient with AIDS. The patient's blood contained 195,000 copies of HIV RNA, 1×10 6 IU hepatitis C virus (HCV) RNA, and 10 7 copies of parvovirus B19 DNA per 1ml plasma. It was positive for cytomegalovirus virus and evidence of a resolved hepatitis B virus (HBV) infection was found. HCV viremia was detected in the physician 15 days later and was not resolved by seroconversion after 57 days. HIV infection was not transmitted, possibly because of the immediate use of anti-HIV prophylactic drugs after exposure. Parvovirus B19 infection was presumably prevented by pre-existing specific antibodies in the patient. Considering that many HIV carriers are coinfected with hepatitis B and C viruses, this case report support the knowledge that the risk of HCV transmission from a patient with AIDS is greater than that of HIV.
机译：由血液传播的病毒（例如乙型和丙型肝炎病毒）和人类免疫缺陷病毒（HIV）引起的感染通常与针刺伤害有关，尤其是在医院环境中。对一名医生进行了前瞻性调查，该医生在从艾滋病患者的血液采集过程中意外针刺受伤。病人的血液每1ml血浆中含有195,000份HIV RNA，1×10 6 IU丙型肝炎病毒（HCV）RNA和> 10 7份细小病毒B19 DNA。它对巨细胞病毒呈阳性，并发现已解决乙型肝炎病毒（HBV）感染的证据。 15天后在医生中检测到HCV病毒血症，但57天后仍无法通过血清转化解决。没有传播艾滋病毒感染，可能是因为暴露后立即使用了抗艾滋病毒预防药物。推测细小病毒B19感染是通过在患者中预先存在的特异性抗体来预防的。考虑到许多艾滋病毒携带者同时感染了乙型和丙型肝炎病毒，因此该病例报告支持这样的认识，即艾滋病患者传播HCV的风险大于艾滋病毒。

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