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首页> 外文期刊>Journal of Medical Virology >Shift in the hepatitis B virus genotype distribution in the last decade among the HBV carriers from eastern India: Possible effects on the disease status and hbv epidemiology
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Shift in the hepatitis B virus genotype distribution in the last decade among the HBV carriers from eastern India: Possible effects on the disease status and hbv epidemiology

机译：近十年来印度东部乙肝病毒携带者中乙肝病毒基因型分布的变化：对疾病状况和乙型肝炎流行病学的可能影响

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摘要

In a previous study from eastern India, the prevalence of HBV/C has been increasing among the blood donors. In order to analyze whether there has been any shift in HBV genotype distributions in recent years, the HBV genotypes prevalent during the periods 2000-2002 (Group-I; n = 176) and 2007-2009 (Group-II; n = 203) were compared, with special attention to changes in the proportion of HBV/C. The rate of prevalence of the three HBV genotypes (A, C, and D; percent prevalence 19.9/21.6/58.5 in Group-I vs. 31.0/28.6/40.4 in Group-II) underwent significant changes with increases in HBV/A and HBV/C among the HBV carriers (0.002). Among the asymptomatic carriers, the prevalence of these two genotypes (P = 0.021 for HBV/A and P = 0.005 for HBV/C) was significantly high. A notable increase was also observed among the chronic liver disease cases. HBV/A increased significantly among the older age Groups (≥51 years), whereas the increase of HBV/C was significant among the younger age Groups (≤20 years). With the increase of HBV/A and HBV/C, the rates of basal core promoter double mutation (1762T/1764A) also increased considerably. Binary logistic regression analysis revealed that both HBV/A and 1762T/1764A mutations are predictors of chronic liver disease state over asymptomatic carrier state. Thus, this study highlights the possible influence of HBV genotype shift on the changing scenario of HBV epidemiology and disease in the population.
机译：在先前来自印度东部的一项研究中，献血者中HBV / C的流行一直在增加。为了分析近年来HBV基因型分布是否有任何变化，HBV基因型在2000-2002年（I组; n = 176）和2007-2009年（II组; n = 203）期间盛行比较了HBV / C比例的变化。三种HBV基因型的流行率（A，C和D; I组患病率19.9 / 21.6 / 58.5与II组患病率31.0 / 28.6 / 40.4）随着HBV / A和HBV携带者中的HBV / C（0.002）。在无症状携带者中，这两种基因型的患病率（HBV / A为P = 0.021，HBV / C为P = 0.005）。在慢性肝病病例中也观察到显着增加。 HBV / A在老年组（≥51岁）中显着增加，而HBV / C在年轻组（≤20岁）中显着增加。随着HBV / A和HBV / C的增加，基础核心启动子双突变（1762T / 1764A）的发生率也显着增加。二进制逻辑回归分析表明，HBV / A和1762T / 1764A突变都是无症状携带者状态下慢性肝病状态的预测因子。因此，本研究强调了HBV基因型转移对人群HBV流行病学和疾病变化情况的可能影响。

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