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首页> 外文期刊>Journal of Medicinal and Aromatic Plant Sciences >Studies on anxiolytic and nootropic effects of successive chloroform and methanolic extracts of Mitragyna parvifolia (Roxb) Korth leaves.
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Studies on anxiolytic and nootropic effects of successive chloroform and methanolic extracts of Mitragyna parvifolia (Roxb) Korth leaves.

机译：香附叶连续氯仿和甲醇提取物的抗焦虑和促智作用研究。

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摘要

Anxiolytic and nootropic properties of successive chloroform and methanolic extracts of Mitragyna parvifolia leaves is reported here. The test groups were orally administered the successive chloroform and methanolic extracts at 200 mg/kg and 400 mg/kg doses. The anxiolytic activity was studied using the mice models of elevated plus maze and basal locomotor score. The nootropic activity was evaluated using the rat model of elevated plus maze. The results were compared using the reference drug, diazepam (1 mg/kg orally) for anxiolytic activity and piracetam (100 mg/kg, orally) for nootropic activity determination. The successive chloroform extract showed significant anxiolytic activity in a dose-dependent manner. The anxiolytic activity of successive methanolic extract was also found to be significant at dose level of 400 mg/kg. However, the successive methanolic extract administered orally at doses of 200 mg/kg and 400 mg/kg orally produced a significant (P<0.05) dose dependent enhancement in cognition in the test animals. A significant decrease in anxiety produced by both the test doses of the successive chloroform extract showed potential anxiolytic action. The depression in anxiety and enhancement in the cognition of test animals treated with successive methanolic extract proved the usefulness of this extract both as a potential anxiolytic and nootropic agent.
机译：在此报道了连续的Mitragyna parvifolia叶的氯仿和甲醇提取物的抗焦虑和促智特性。分别以200 mg / kg和400 mg / kg的剂量口服给予连续三氯仿和甲醇提取物的测试组。使用升高的迷宫和基础运动评分的小鼠模型研究抗焦虑活性。使用高架迷宫大鼠模型评估促智活性。使用参考药物地西epa（1 mg / kg口服）的抗焦虑活性和吡乙酰胺（100 mg / kg口服）的促智活性进行比较。连续的氯仿提取物以剂量依赖性方式显示出显着的抗焦虑活性。还发现连续的甲醇提取物的抗焦虑活性在400mg / kg的剂量水平下是显着的。但是，以200 mg / kg和400 mg / kg的口服剂量连续给药的甲醇提取物在测试动物中产生了显着（P <0.05）剂量依赖性的认知增强。两次试验剂量的连续氯仿提取物所产生的焦虑显着降低，显示出潜在的抗焦虑作用。用连续的甲醇提取物治疗的试验动物的焦虑降低和认知增强证明了该提取物作为潜在的抗焦虑药和促智药都是有用的。

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