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首页> 外文期刊>The Tohoku Journal of Experimental Medicine >Donor-Derived Regulatory T Cells Attenuate the Severity of Acute Graft-Versus-Host Disease after Cord Blood Transplantation
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Donor-Derived Regulatory T Cells Attenuate the Severity of Acute Graft-Versus-Host Disease after Cord Blood Transplantation

机译：供体来源的调节性T细胞减轻脐带血移植后急性移植物抗宿主病的严重性

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摘要

Allogeneic peripheral blood stem cell transplantation (allo-PBSCT) is a curative therapy for some types of hematological disorders. However, allo-PBSCT is commonly complicated with acute graft-versus-host disease (aGVHD), characterized by host tissues being attacked by the grafted donor lymphocytes due to disparities of human leukocyte antigen (HLA) between the donor and host. By contrast, cord blood transplantation (CBT) is typically associated with low-grade severity of aGVHD, but the underlying mechanisms remain unclear. Donor-derived CD4(+) alloreactive T cells (ATs) are of a specific lymphocyte subset, which can be activated by the recipient's HLA, and play a crucial role in the onset of aGVHD. In the present study, we aimed to explore the difference in the property of CD4(+)ATs between cord blood (CB) and adult peripheral blood (APB). We thus found that CB and APB CD4(+)ATs contained not only effector T cells (Teffs) that execute aGVHD, but also a distinct subset of FoxP3(+) regulatory T cells (Tregs) that may alleviate aGVHD. Importantly, CB CD4(+)ATs contained higher percentage of FoxP3(+) Tregs, compared to APB CD4(+) ATs (P < 0.001), while lower percentage of Teffs (Th1, Th2 and Th17 cells) was detected in CB CD4(+) ATs (P < 0.05, P < 0.001 and P < 0.05, respectively). Our findings suggest that FoxP3(+) Tregs in CB CD4(+) ATs may contribute to attenuating the severity of aGVHD observed after CBT.
机译：同种异体外周血干细胞移植（allo-PBSCT）是治疗某些类型血液疾病的一种有效疗法。然而，同种异体PBSCT通常并发急性移植物抗宿主病（aGVHD），其特征是宿主细胞由于供体与宿主之间人白细胞抗原（HLA）的差异而被移植的供体淋巴细胞攻击。相比之下，脐带血移植（CBT）通常与aGVHD的低度严重程度相关，但其潜在机制仍不清楚。供体来源的CD4（+）同种异体反应性T细胞（AT）具有特定的淋巴细胞亚群，可以被受体的HLA激活，并在aGVHD的发作中起关键作用。在本研究中，我们旨在探讨脐带血（CB）和成人外周血（APB）之间CD4（+）ATs的特性差异。因此，我们发现CB和APB CD4（+）ATs不仅包含执行aGVHD的效应T细胞（Teff），而且还包含可以缓解aGVHD的FoxP3（+）调节T细胞（Treg）的独特子集。重要的是，与APB CD4（+）AT相比，CB CD4（+）ATs包含更高百分比的FoxP3（+）Treg（P <0.001），而在CB CD4中检测到Teff的百分比较低（Th1，Th2和Th17细胞）。 （+）AT（分别为P <0.05，P <0.001和P <0.05）。我们的发现表明，CB CD4（+）AT中的FoxP3（+）Treg可能有助于减弱CBT后观察到的aGVHD的严重程度。

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