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首页> 外文期刊>Journal of medicinal food >Effects of in utero exposure to D-004, a lipid extract from Roystonea regia fruits, in the male rat: a comparison with finasteride.
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Effects of in utero exposure to D-004, a lipid extract from Roystonea regia fruits, in the male rat: a comparison with finasteride.

机译：宫内暴露于雄性大鼠D-004（一种来自贵妃果实的脂质提取物）的作用：与非那雄胺的比较。

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摘要

D-004 is a lipid extract obtained from Cuban royal palm fruits, consisting of a mixture of free fatty acids, that prevents prostate hyperplasia induced with testosterone in rodents. This study investigated the possible alterations due to D-004 of androgen-dependent development after exposure in utero and compared them with those due to finasteride. Rats were randomized into five experimental groups: a control group, three groups treated with D-004 at 500, 750, or 1,000 mg/kg/day, respectively, and a group treated with finasteride (10 mg/kg/day). Male rats were treated 10 weeks before and during mating. Female rats were treated for 15 days prior mating, during mating, during pregnancy, and until lactation (day 21) except for those treated with finasteride, which were only administered the drug on gestational days 12-21. All male offspring were monitored individually until necropsy after postnatal day 90. The results of the present study indicate that D-004 induced no alterations in androgen-dependent development after the exposure in utero. Also, the current study demonstrated a permanent reduction in anogenital distance and retention of nipples in adult male rats exposed to finasteride during late gestation. Significant alterations induced by exposure to finasteride were mainly in tissues dependent on dihydrotestosterone during development.
机译：D-004是从古巴皇家棕榈果中提取的脂质提取物，由游离脂肪酸的混合物组成，可防止啮齿动物中睾丸激素诱发的前列腺增生。这项研究调查了子宫内暴露于雄激素依赖性发育的D-004引起的可能变化，并将其与非那雄胺引起的变化进行了比较。将大鼠随机分为五个实验组：对照组，分别以500、750或1,000 mg / kg / day用D-004治疗的三组和以非那雄胺（10 mg / kg / day）治疗的组。在交配前和交配期间对雄性大鼠进行治疗10周。雌性大鼠在交配前，交配中，怀孕期间和哺乳期（第21天）治疗15天，除非那雄胺治疗只在妊娠第12-21天给药。单独监测所有雄性后代，直到出生后第90天尸检。本研究结果表明，D-004在子宫内暴露后，其雄激素依赖性发育没有改变。另外，当前的研究表明，在妊娠后期暴露于非那雄胺的成年雄性大鼠中，肛门生殖器距离和乳头固位永久减少。暴露于非那雄胺引起的显着改变主要是在发育过程中依赖于二氢睾丸激素的组织中。

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