Stress Imaging in Men with Hypertrophic Cardiomyopathy and Erectile Dysfunction

Tomas Konecny; Ajay Nehra; Patricia A. Pellikka; Steve R. Ommen; Stephen L. Kopecky

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Stress Imaging in Men with Hypertrophic Cardiomyopathy and Erectile Dysfunction

机译：肥厚性心肌病和勃起功能障碍男性的应激显像

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Background: The management of erectile dysfunction in men with hypertrophic cardiomyopathy remains controversial, since phosphodiesterase 5 inhibitors can theoretically increase left ventricular outflow tract pressure gradient (PG), yet this increase may not be detected at rest.Case Description: Two hemodynamic supine bike stress tests with transthoracic echocardiography were performed on two subsequent mornings in a 65-year-old man with hypertrophic cardiomyopathy and episodes of presyncope. The patient was instructed to take Tadalafil before the first stress test, and Tadalafil and Vardenafil before the second stress test.Results: The left ventricular outflow tract PG recorded by continuous-wave Doppler in the transapical view increased between rest and peak exercise: APG on Tadalafil = +37mmHg; APG on Tadalafil and Vardenafil = +124mmHg.Conclusion: This report demonstrates a novel use of serial provocation imaging studies aimed at comparing left ventricular PGs at peak stress during the initiation and dose titration of phosphodiesterase 5 inhibitors. Further studies are needed to develop an evidence-guided algorithm for safe implementation of therapies for erectile dysfunction in this most common inherited cardiomyopathy.

机译：背景：肥厚型心肌病男性勃起功能障碍的治疗仍存在争议，因为理论上磷酸二酯酶5抑制剂可增加左心室流出道压力梯度（PG），但在静息状态下可能无法检测到这种增加。在随后的两个早晨，对一名65岁肥厚型心肌病和晕厥前发作的男子进行了经胸超声心动图检查。指导患者在第一次压力测试之前服用他达拉非，在第二次压力测试之前服用他达拉非和伐地那非。结果：在休息和峰值运动之间，连续波多普勒在经心尖视图中记录的左心室流出道PG增加：他达拉非= + 37mmHg; Tadalafil和Vardenafil = + 124mmHg上的APG。结论：本报告证明了一系列激发成像研究的新颖用途，旨在比较磷酸二酯酶5抑制剂的起始和剂量滴定期间左心室PG在峰值应力下的作用。需要开展进一步的研究来开发一种证据指导的算法，以在这种最常见的遗传性心肌病中安全实施勃起功能障碍的疗法。

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《Journal of men’s health.》 |2013年第4期|共2页
作者
Tomas Konecny; Ajay Nehra; Patricia A. Pellikka; Steve R. Ommen; Stephen L. Kopecky;
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正文语种 eng
中图分类人体生理学;
关键词
erectile dysfunction; hypertrophic cardiomyopathy; phosphodiesterase 5 inhibitors;

机译：勃起功能障碍;肥厚性心肌病;磷酸二酯酶5抑制剂;

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1. Stress Imaging in Men with Hypertrophic Cardiomyopathy and Erectile Dysfunction [J] . Tomas Konecny, Ajay Nehra, Patricia A. Pellikka, Journal of men’s health. . 2013,第4期

机译：肥厚性心肌病和勃起功能障碍男性的应激显像
2. Coronary microvascular dysfunction in hypertrophic cardiomyopathy detected by Rubidium-82 positron emission tomography and cardiac magnetic resonance imaging [J] . Moody William E., Schmitt Matthias, Arumugam Parthiban Journal of nuclear cardiology: official publication of the American Society of Nuclear Cardiology . 2019,第2期

机译：Rubidium-82正电子发射断层扫描和心脏磁共振成像检测冠状动脉微血管病变
3. Diastolic Dysfunction of Hypertrophic Cardiomyopathy Genotype‐Positive Subjects Without Hypertrophy Is Detected by Tissue Doppler Imaging: A Systematic Review and Meta‐analysis [J] . Wen Liu, Dandan Sun, Jun Yang Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine . 2017,第10期

机译：组织 D oppler成像检测到肥厚性心肌病基因型阳性无肥厚性的舒张功能障碍：系统评价和荟萃分析
4. Determination of Image-based Biomarkers for the Diagnosis of Hypertrophic Cardiomyopathy, Hypertensive Cardiomyopathy and Amyloidosis From Texture Analysis in Cardiac MRI [C] . Inés Vidal-Sospedra, Silvia Ruiz-España, Tania Piñeiro-Vidal, IEEE International Conference on Bioinformatics and Bioengineering . 2020

机译：基于形象的生物标志物在心脏MRI纹理分析中诊断肥厚性心肌病变，高血压心肌病和淀粉样蛋白病
5. The relationship between erectile function, traditional masculine ideology, and marital satisfaction among younger and older Taiwanese men with erectile dysfunction. [D] . Wang, Paul Song Cherng. 2008

机译：台湾年轻和较老的勃起功能障碍男性的勃起功能，传统男性意识形态和婚姻满意度之间的关系。
6. Coronary microvascular dysfunction in hypertrophic cardiomyopathy detected by Rubidium-82 positron emission tomography and cardiac magnetic resonance imaging [O] . William E. Moody, Matthias Schmitt, Parthiban Arumugam -1

机译：Rub82正电子发射断层显像和心脏磁共振成像检测肥厚型心肌病的冠状动脉微血管功能障碍
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Stress Imaging in Men with Hypertrophic Cardiomyopathy and Erectile Dysfunction

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