...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular and Cellular Cardiology >A functional role for transverse (t-) tubules in the atria.
【24h】

A functional role for transverse (t-) tubules in the atria.

机译：心房中横向（t-）小管的功能性作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mammalian ventricular myocytes are characterised by the presence of an extensive transverse (t-) tubule network which is responsible for the synchronous rise of intracellular Ca(2+) concentration ([Ca(2+)]i) during systole. Disruption to the ventricular t-tubule network occurs in various cardiac pathologies and leads to heterogeneous changes of [Ca(2+)]i which are thought to contribute to the reduced contractility and increased susceptibility to arrhythmias of the diseased ventricle. Here we review evidence that, despite the long-held dogma of atrial cells having no or very few t-tubules, there is indeed an extensive and functionally significant t-tubule network present in atrial myocytes of large mammals including human. Moreover, the atrial t-tubule network is highly plastic in nature and undergoes far more extensive remodelling in heart disease than is the case in the ventricle with profound consequences for the resulting systolic Ca(2+) transient. In addition to considering the functional role of the t-tubule network in the healthy and diseased atria we also provide an overview of recent data concerning the putative factors controlling the formation of t-tubules and conclude by posing some important questions that currently remain to be addressed and whether or not targeting t-tubules offers potential novel therapeutic possibilities for heart disease.
机译：哺乳动物的心室肌细胞的特征是存在广泛的横向（t-）肾小管网络，其负责收缩期间细胞内Ca（2+）浓度（[Ca（2 +）] i）的同步上升。对心室t管网络的破坏发生在各种心脏病理学中，并导致[Ca（2 +）] i的异质变化，据认为这有助于降低收缩性和增加患病心律失常的易感性。在这里，我们回顾了证据，尽管长期以来不存在或几乎没有t管的心房细胞教条，实际上在包括人在内的大型哺乳动物的心房肌细胞中确实存在着广泛而功能上重要的t管网络。此外，心房t管网络本质上是高度可塑性的，并且在心脏病中比在心室中经历更广泛的重塑，对产生的收缩期Ca（2+）瞬变具有深远的影响。除了考虑t管网络在健康和患病心房中的功能作用之外，我们还概述了有关控制t管形成的假定因素的最新数据，并提出了一些目前尚待解决的重要问题作为结论。以及是否靶向t管可以为心脏病提供潜在的新颖治疗方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号