Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing

Pfeiffer E. R.; Wright A. T.; Edwards A. G.; Stowe J. C.; McNall K.; Tan J.; Niesman I.; Patel H. H.; Roth D. M.; Omens J. H.; McCulloch A. D.

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Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing

机译：舒张依赖性传导减慢需要心室肌细胞中的小窝

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Mechanical stretch of cardiac muscle modulates action potential propagation velocity, causing potentially arrhythmogenic conduction slowing. The mechanisms by which stretch alters cardiac conduction remain unknown, but previous studies suggest that stretch can affect the conformation of caveolae in myocytes and other cell types. We tested the hypothesis that slowing of action potential conduction due to cardiac myocyte stretch is dependent on caveolae.

机译：心肌的机械拉伸调节动作电位的传播速度，从而导致潜在的致心律失常传导减慢。拉伸改变心脏传导的机制仍然未知，但是以前的研究表明，拉伸可以影响肌细胞和其他细胞类型中小窝的构象。我们检验了以下假设：由于心肌细胞伸展而导致动作电位传导减慢取决于小窝。

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《Journal of Molecular and Cellular Cardiology》 |2014年第null期|共10页
作者
Pfeiffer E. R.; Wright A. T.; Edwards A. G.; Stowe J. C.; McNall K.; Tan J.; Niesman I.; Patel H. H.; Roth D. M.; Omens J. H.; McCulloch A. D.;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Cardiac mechanoelectric feedback; Caveolae; Capacitance;

机译：心脏机电反馈;腔隙;电容;

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专利

1. Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing [J] . Pfeiffer E. R., Wright A. T., Edwards A. G., Journal of Molecular and Cellular Cardiology . 2014,第Null期

机译：舒张依赖性传导减慢需要心室肌细胞中的小窝
2. Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation [J] . Burton Rebecca A. B., Rog-Zielinska Eva A., Corbett Alexander D., Biophysical Journal . 2017,第5期

机译：Caveolae在兔心室肌细胞：细胞分离后的分布和动态减少
3. Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte [J] . MacDougallD.A., AgarwalS.R., StopfordE.A., Journal of Molecular and Cellular Cardiology . 2012,第2期

机译：通过减少cAMP的产生并维持成年心室肌细胞的肌质网中的磷酸酶活性，使小窝分隔β2-肾上腺素受体信号
4. A fibroblast-myocyte model which accounts for slow conduction and fractionated electrograms in infarct border zones [C] . Vasquez, C., Siddiqui, . 2002

机译：成纤维细胞-心肌细胞模型，说明梗塞边界区传导缓慢和电描记图分离
5. Mechanisms of slowed conduction during ventricular volume loading. [D] . Mills, Robert W. 2006

机译：心室容积负荷期间传导减慢的机制。
6. Caveolae in Ventricular Myocytes are Required for Stretch-Dependent Conduction Slowing [O] . E.R. Pfeiffer, A.T. Wright, A.G. Edwards, -1

机译：舒张依赖性传导减慢需要室肌细胞中的小窝。
7. Myocyte Stretch Slows Cardiac Conduction by a Caveolae-Dependent Increase in Sarcolemmal Capacitance [O] . Pfeiffer Emily, Wright Adam, Edwards Andrew, 2014

机译：肌细胞舒张通过肌膜小管电容的小窝依赖性增加减慢了心脏传导。

Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing

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