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首页> 外文期刊>Journal of Molecular and Cellular Cardiology >Protein Quality Control, The Ubiquitin Proteosome System, and Authophagy: When Worlds Collide
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Protein Quality Control, The Ubiquitin Proteosome System, and Authophagy: When Worlds Collide

机译：蛋白质质量控​​制，泛素蛋白酶体系统和自噬：当世界碰撞时

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This special issue entitled "Protein quality control, the ubiquitin pro-teasome system, and autophagy" represents the contributions of more than a dozen leading clinical and translational experts discussing the converging fields of protein quality control, the ubiquitin proteasome system, and autophagy. These up-to-date and comprehensive summaries are presented for cardiovascular scientists and clinicians alike with limited exposure to this new and exciting field.While the homeostasis of the intracellular protein milieu is conceptually appreciated, its practical utility in the heart has only emerged in the past five years. In the first article by Sandri and Robbins [1], the "life cycle" of proteins is discussed, from protein synthesis, post-translational processing and transport, folding, assembly, stress, and clearance - the sum of which make up the concept of protein quality control.
机译：本期名为“蛋白质质量控​​制，泛素蛋白酶体系统和自噬”的专刊代表了十几位领先的临床和转化专家的贡献，他们讨论了蛋白质质量控​​制，泛素蛋白酶体系统和自噬的融合领域。这些最新的和全面的摘要是为心血管科学家和临床医生提供的，但在这一新的激动人心的领域中所受的接触有限。虽然从概念上赞赏了细胞内蛋白质环境的稳态，但其在心脏中的实用性才出现在心脏中。过去五年。在Sandri和Robbins的第一篇文章[1]中，讨论了蛋白质的“生命周期”，从蛋白质合成，翻译后加工和运输，折叠，组装，应力和清除-这些总和构成了概念蛋白质质量控​​制。

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