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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Dual role of sequence-dependent DNA curvature in nucleosome stability: the critical test of highly bent Crithidia fasciculata DNA tract.
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Dual role of sequence-dependent DNA curvature in nucleosome stability: the critical test of highly bent Crithidia fasciculata DNA tract.

机译：序列依赖性DNA曲率在核小体稳定性中的双重作用：高度弯曲的Crithidia fasciculata DNA束的关键测试。

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摘要

In spite of the knowledge of the nucleosome molecular structure, the role of DNA intrinsic curvature in determining nucleosome stabilization is still an open question. In this paper, we describe a general model that allows the prediction of the nucleosome stability, tested on 83 different DNA sequences, in surprising good agreement with the experimental data, carried out in ours as well as in many other laboratories. The model is based on the dual role of DNA curvature in nucleosome thermodynamic stabilization. A critical test is the evaluation of the nucleosome free energy relative to a Crithidia fasciculata kinetoplast DNA fragment, which represents the most curved DNA found so far in biological systems and, therefore, is generally believed to form a highly stable nucleosome.
机译：尽管了解核小体的分子结构，但DNA固有曲率在确定核小体稳定性方面的作用仍是一个悬而未决的问题。在本文中，我们描述了一个可预测核小体稳定性的通用模型，该模型在83个不同的DNA序列上进行了测试，与我们以及许多其他实验室进行的实验数据出乎意料的良好一致性。该模型基于DNA曲率在核小体热力学稳定中的双重作用。一项关键测试是评估相对于Crisidia fasciculata运动塑料DNA片段的核小体自由能，该片段代表了迄今为止在生物系统中发现的最弯曲的DNA，因此通常被认为形成了高度稳定的核小体。

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