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首页> 外文期刊>Journal of Molecular Liquids >Synthesis, spectroscopic characterizations and biological activities of vanadyl(II) folate compound as a new anti-DNA damage and antioxidant agent
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Synthesis, spectroscopic characterizations and biological activities of vanadyl(II) folate compound as a new anti-DNA damage and antioxidant agent

机译：叶酸钒（II）化合物的合成，光谱表征和生物学活性

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摘要

New oxovanadium(IV) folate [(VO)(2)(FO) (NH4)(2)(SO4)(2)] complex was synthesized by the reaction between vanadyl(II) sulfate and folic acid vitamin B-9 drug in an alkaline media. Elemental analysis shows 1:2 ligand to metal ion stoichiometry and the conductance data deduced that oxovanadium(IV) folate complex has non electrolytic nature. IR spectrum of oxovanadium(IV) complex reveal that folic acid acts as a binuclear chelate via deprotonation of both carboxylic groups. The biological section aimed to test the toxicity of carbofuran orally for male rat and oxidative stress of the sub-lethal (2.4 mg/kg b.w, 1/25 LD50) dose on the lipid peroxidation level (LPO), reduced glutathione content (GSH), antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities of testicular tissue. The protective efficiency of vanadylfolate (50 mg/kg b.w) only or combined together carbofuran was tested. The taken of carbofuran orally led to elevation in LPO level by 2.10 fold in comparable with control. The efficient of antioxidant enzymes using of vanadylfolate in combined with carbofuran or its only were decreased by (25.48%, 18.60%, 22.46% and 16.62%) but the GSH level increased by 37.18% in testicular tissue in comparison with controller sample. The DNA damaging of carbofuran and vanadylfolate were assessed using single cell gel electrophoresis (SCGE) data. (c) 2016 Elsevier B.V. All rights reserved.
机译：叶酸钒（II）与叶酸维生素B-9药物的反应合成了新的叶酸氧钒（IV）[（VO）（2）（FO）（NH 4）（2）（SO 4）（2）]络合物。碱性介质。元素分析表明金属离子化学计量比为1：2，并且电导数据推导叶酸氧钒（IV）配合物具有非电解性质。氧钒（IV）配合物的红外光谱表明，叶酸通过两个羧基的去质子化作用充当双核螯合物。生物部分旨在测试口服呋喃丹对雄性大鼠的毒性以及亚致死剂量（2.4 mg / kg bw，1/25 LD50）对脂质过氧化水平（LPO），谷胱甘肽含量（GSH）降低的氧化应激，睾丸组织的抗氧化酶，超氧化物歧化酶（SOD），过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPx）和谷胱甘肽S-转移酶（GST）活性。测试了仅钒酸叶酯（50 mg / kg b.w）或与呋喃丹合用的保护效果。口服呋喃丹可导致LPO水平升高2.10倍，与对照组相当。与对照样品相比，钒酸叶酸与呋喃丹或仅与呋喃丹合用的抗氧化酶的效率降低了（25.48％，18.60％，22.46％和16.62％），但GSH水平升高了37.18％。使用单细胞凝胶电泳（SCGE）数据评估了呋喃呋喃和钒酸叶酯的DNA损伤。 （c）2016 Elsevier B.V.保留所有权利。

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