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首页> 外文期刊>Journal of molecular medicine: Official organ of the "Gesellschaft Deutscher Naturforscher und Arzte." >Using pharmacogenetics and pharmacogenomics in the treatment of psychiatric disorders: some ethical and economic considerations.
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Using pharmacogenetics and pharmacogenomics in the treatment of psychiatric disorders: some ethical and economic considerations.

机译：在精神疾病中使用药物遗传学和药物基因组学：一些道德和经济方面的考虑。

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Current pharmacotherapies for psychiatric disorders are generally incompletely effective. Many patients do not respond well or suffer adverse reactions to these drugs, which can result in poor patient compliance and poor treatment outcome. Adverse drug reactions and non-response are likely to be influenced by genetic polymorphisms. Pharmacogenetics holds some promise for improving the treatment of mood disorders by utilising information about genetic polymorphisms to match patients to the drug therapy that is the most effective with the fewest side effects. Pharmacogenomics promises to facilitate the development of new drugs for treatment. However, these technologies raise many ethical, economic and regulatory issues that need to be addressed before they can be integrated into psychiatry, and medicine more generally. We discuss ethical and policy issues arising from pharmacogenetic testing and pharmacogenomics research, such as informed consent, privacy and confidentiality, research on vulnerable persons and discrimination; and economic viability of pharmacogenetics and pharmacogenomics. We conclude with recommendations for the regulation and distribution of pharmacogenetic testing services and pharmacogenomic drugs.
机译：当前用于精神疾病的药物治疗通常是不完全有效的。许多患者对这些药物反应不良或遭受不良反应，这可能导致患者依从性差和治疗效果差。药物不良反应和无反应可能受到遗传多态性的影响。药物遗传学有望通过利用有关遗传多态性的信息来使患者接受最有效，副作用最少的药物治疗，从而改善情绪障碍的治疗。药物基因组学有望促进治疗新药的开发。但是，这些技术提出了许多伦理，经济和法规问题，在将它们整合到精神病学和更广泛的医学领域之前，需要解决这些问题。我们讨论了由药物遗传学测试和药物基因组学研究引起的道德和政策问题，例如知情同意，隐私和保密，对弱势群体和歧视的研究;药物遗传学和药物基因组学的经济可行性。最后，我们提出了有关药物遗传学检测服务和药物基因组学药物的监管和分销的建议。

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