Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

BartlJ.; MüllerT.; GrünblattE.; GerlachM.; RiedererP.

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Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

机译：慢性单胺氧化酶-B抑制剂治疗可阻断单胺氧化酶-A酶活性

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Patients with Parkinson's disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.

机译：帕金森氏病患者接受选择性不可逆的单胺氧化酶（MAO）-B抑制剂，但在长期应用期间其对MAO-A活性的影响尚不清楚。我们确定了血浆样品中MAO-A的抑制作用，该血浆样品来自摄入MAO-B抑制剂或未进行MAO-B抑制剂治疗的患者以及健康对照。与其他组相比，我们发现使用MAO-B抑制剂治疗的患者的MAO-A活性降低了70％。我们的结果表明，每天给药时，使用MAO-B抑制剂治疗也可能影响体内的MAO-A活性。

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《Journal of neural transmission》 |2014年第4期|共5页
作者
BartlJ.; MüllerT.; GrünblattE.; GerlachM.; RiedererP.;
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正文语种 eng
中图分类人体形态学;
关键词
MAO-A; MAO-B inhibitors; Parkinson's disease; Rasagiline; Selegiline;

机译：MAO-A;MAO-B抑制剂;帕金森氏病;雷沙吉兰;司来吉兰;

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1. Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity [J] . BartlJ., MüllerT., GrünblattE., Journal of neural transmission . 2014,第4期

机译：慢性单胺氧化酶-B抑制剂治疗可阻断单胺氧化酶-A酶活性
2. High-throughput screening for monoamine oxidase-A and monoamine oxidase-B inhibitors using one-step fluorescence assay [J] . Hong-mei GUANG, Guan-hua DU 中国药理学报：英文版 . 2006,第006期

机译：使用一步荧光法高通量筛选单胺氧化酶-A和单胺氧化酶-B抑制剂
3. SL25.1131 [3(S),3a(S)-3-Methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one],a New,Reversible,and Mixed Inhibitor of Monoamine Oxidase-A and Monoamine Oxidase-B:Biochemical and Behavioral Profile [J] . N.Aubin, P.Barneoud, C.Carter The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2004,第3期

机译：SL25.1131 [3（S），3a（S）-3-Methoxymethyl-7- [4,4,4-trifluorobutoxy] -3,3a，4,5-tetrahydro-1,3-oxazolo [3,4- a] quinolin-1-one]，一种新型，可逆的单胺氧化酶-A和单胺氧化酶-B的混合抑制剂：生化和行为特征
4. Quantitative Structure Activity Relationship of New 7-Oxycoumarin Derivatives As Potent and Selective Monoamine Oxidase A Inhibitors [C] . Xianchao Li, Hongzong Si, Hua Gao International Forum on Materials Science and Industrial Technology . 2013

机译：新的7-Oxycoumarin衍生物作为有效和选择性单胺氧化酶氧化酶的定量结构活性关系
5. Comparative mechanistic and structural approaches to investigate the membrane-bound enzymes monoamine oxidase A and monoamine oxidase B. [D] . Li, Min. 2005

机译：比较机制和结构的方法来研究膜结合酶单胺氧化酶A和单胺氧化酶B.
6. Increased total activity in the rat after L-tryptophan plus the monoamine oxidase-A inhibitor amiflamine but not after L-tryptophan plus clorgyline. [O] . T. Archer, C. J. Fowler, A. Fredriksson, 1985

机译：L-色氨酸加单胺氧化酶-A抑制剂amiflamine后大鼠总活性增加但L-色氨酸加高锰酸胆碱后则没有。
7. Inhibition of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine metabolic activity of porcine FAD-containing monooxygenase by selective monoamine oxidase-B inhibitors [O] . Wu Ru-Feng, Ichikawa Yoshiyuki 1995

机译：选择性单胺氧化酶-B抑制剂抑制猪含FAD的单加氧酶的1-甲基-4-苯基-1,2,3,6-四氢吡啶代谢活性

Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

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