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首页> 外文期刊>Journal of Molecular Biology >Alternative splicing of an amino-terminal PEVK-like region generates multiple isoforms of Drosophila projectin.
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Alternative splicing of an amino-terminal PEVK-like region generates multiple isoforms of Drosophila projectin.

机译：氨基末端PECK-lake区域的可变剪接产生果蝇投影的多个同工型。

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摘要

Drosophila projectin is an extremely large protein found within the muscle sarcomeric unit, parallel with the actin and myosin filaments. Projectin has been suggested as the elastic component of C-filaments in insect indirect flight muscles, which is consistent with its localization from the Z band to the tip of the A band in these muscles. Here, we describe the completion of the projectin sequence analysis, which defines projectin as a 1 MDa protein, composed of 39 immunoglobulin and 39 fibronectin III domains. This analysis led also to the identification of a domain rich in the amino acids P, E, V and K within the NH(2) terminus of projectin. The length of the projectin PEVK-like region varies from 100 to 624 amino acid residues, following a complex pattern of alternative splicing events. PEVK domains were first identified in vertebrate titin and they have been associated with the elasticity of the protein. The PEVK-like domain of the projectin isoforms in indirect flight muscles may contribute to the elastic function of the C-filaments. The synchronous projectin isoforms contain a PEVK-like region, and the possible non-elastic function(s) of this domain in synchronous muscles are discussed.
机译：果蝇投影蛋白是在肌肌节单元内发现的一种非常大的蛋白质，与肌动蛋白和肌球蛋白丝平行。投影素已被建议作为昆虫间接飞行肌肉中C丝的弹性成分，这与其在这些肌肉中从Z带到A带尖端的定位一致。在这里，我们描述了projectin序列分析的完成，该分析将projectin定义为1个MDa蛋白，由39个免疫球蛋白和39个纤连蛋白III结构域组成。该分析还导致鉴定了在projectin NH（2）末端内富含氨基酸P，E，V和K的域。在选择性剪接事件的复杂模式之后，projectin PEVK样区域的长度在100至624个氨基酸残基之间变化。 PEVK结构域首先在脊椎动物的titin中鉴定，它们与蛋白质的弹性有关。间接飞行肌肉中投射素同工型的PEVK样结构域可能有助于C丝的弹性功能。同步投射蛋白同工型包含一个PEVK样区域，并讨论了同步肌肉中该结构域的可能的非弹性功能。

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