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Does a stretched DNA structure dictate the helical geometry of RecA-like filaments?

机译:拉伸的DNA结构决定了RecA样细丝的螺旋几何形状吗?

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Proteins in the RecA/Rad51/RadA/UvsX family form helical filaments on DNA in which the DNA is stretched and untwisted. A comparison of the average helical parameters of these filaments from five different proteins, obtained from archaea, eubacteria and eukaryotes, suggests that an intrinsic state of DNA may be responsible for the conservation of these particular filament forms across evolution. Ln this view, these proteins stabilize this existing state of DNA, rather than induce a novel conformation. (C) 2001 Academic Press. [References: 21]
机译:RecA / Rad51 / RadA / UvsX家族中的蛋白质在DNA上形成螺旋状细丝,其中DNA被拉伸和不加捻。从古细菌,真细菌和真核生物获得的五种不同蛋白质的这些细丝的平均螺旋参数的比较表明,DNA的固有状态可能负责这些特定细丝形式在进化过程中的保守性。在这种观点下,这些蛋白质稳定了DNA的这种现有状态,而不是诱导出新的构象。 (C)2001学术出版社。 [参考:21]

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