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首页> 外文期刊>Journal of Molecular Biology >Comparison of ARM and HEAT protein repeats.
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Comparison of ARM and HEAT protein repeats.

机译：ARM和HEAT蛋白重复序列​​的比较。

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摘要

ARM and HEAT motifs are tandemly repeated sequences of approximately 50 amino acid residues that occur in a wide variety of eukaryotic proteins. An exhaustive search of sequence databases detected new family members and revealed that at least 1 in 500 eukaryotic protein sequences contain such repeats. It also rendered the similarity between ARM and HEAT repeats, believed to be evolutionarily related, readily apparent. All the proteins identified in the database searches could be clustered by sequence similarity into four groups: canonical ARM-repeat proteins and three groups of the more divergent HEAT-repeat proteins. This allowed us to build improved sequence profiles for the automatic detection of repeat motifs. Inspection of these profiles indicated that the individual repeat motifs of all four classes share a common set of seven highly conserved hydrophobic residues, which in proteins of known three-dimensional structure are buried within or between repeats. However, the motifs differ at several specific residue positions, suggesting important structural or functional differences among the classes. Our results illustrate that ARM and HEAT-repeat proteins, while having a common phylogenetic origin, have since diverged significantly. We discuss evolutionary scenarios that could account for the great diversity of repeats observed.
机译：ARM和HEAT模体是大约50个氨基酸残基的串联重复序列，存在于多种真核蛋白中。对序列数据库的详尽搜索发现了新的家族成员，并发现500个真核蛋白质序列中至少有1个包含此类重复序列。它也使ARM和HEAT重复序列之间的相似性（据信是进化相关的）变得显而易见。在数据库搜索中识别出的所有蛋白质都可以通过序列相似性分为四类：常规的ARM重复蛋白和三组差异更大的HEAT重复蛋白。这使我们能够建立用于自动检测重复基序的改进序列概况。对这些图谱的检查表明，所有四个类别的单个重复基序共有七个高度保守的疏水残基的公共集合，这些残基在已知三维结构的蛋白质中埋在重复序列之内或之间。但是，这些基序在几个特定的​​残基位置上有所不同，表明类别之间存在重要的结构或功能差异。我们的结果表明，尽管ARM和HEAT重复蛋白具有共同的系统发生起源，但此后却发生了巨大的分歧。我们讨论了进化情景，这些情景可以解释观察到的重复序列的多样性。

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