Crystal Structure of the Catalytic Domain of Human ADAM33.

Orth P; Reichert P; Wang W; Prosise WW; Yarosh Tomaine T; Hammond G; Ingram RN; Xiao L; Mirza UA; Zou J; Strickland C; Taremi SS; Le HV; Madison V

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Crystal Structure of the Catalytic Domain of Human ADAM33.

机译：人ADAM33催化域的晶体结构。

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Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.

机译：Adam33是假定的哮喘易感基因，编码属于ADAM家族的膜锚定金属蛋白酶。 ADAM（一种整合蛋白和金属蛋白酶）是糖蛋白家族，与细胞-细胞相互作用，细胞融合和细胞信号传导有关。我们已经确定了与抑制剂marimastat和无抑制剂形式复合的Adam33催化域的晶体结构。该结构揭示了类似于其他金属蛋白酶的多肽折叠和活性位点环境。底物结合位点包含独特的功能，可以对该酶的特定抑制剂进行基于结构的设计。

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来源
《Journal of Molecular Biology》 |2004年第1期|共9页
作者
Orth P; Reichert P; Wang W; Prosise WW; Yarosh Tomaine T; Hammond G; Ingram RN; Xiao L; Mirza UA; Zou J; Strickland C; Taremi SS; Le HV; Madison V;
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正文语种 eng
中图分类基础医学;
关键词
structure; Catalytic Domain; Crystal Structure; Metalloendopeptidases; Human; 催化域;

机译：结构;催化结构域;晶体结构;金属内肽酶;人;催化域;

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1. Crystal Structure of the Catalytic Domain of Human ADAM33. [J] . Orth P, Reichert P, Wang W, Journal of Molecular Biology . 2004,第1期

机译：人ADAM33催化域的晶体结构。
2. High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin. [J] . Andersen OA, Flatmark T, Hough E Journal of Molecular Biology . 2001,第2期

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3. Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. [J] . Tao X, Tong L Protein Science: A Publication of the Protein Society . 2007,第5期

机译：人MKP5的MAP激酶结合结构域和催化结构域的晶体结构。
4. Correlation of domain structure of TGS single crystals doped with serine with its dielectric properties - new constructed computer measuring system for quantity analysis of domain images [C] . W. Proszak, M. Trybus International Conference on Solid State Crystals . 2001

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5. X-ray crystallographic studies of Thermobifida fusca Xeg74 catalytic domain, human UDP-GlcNAc pyrophosphorylase apo-AGX1, and quadruple mutants of staphylococcal nuclease and the structural analysis of clostridial collagenase collagen binding domain and S1 catalytic domain. [D] . Sides, Cynthia RaJeana. 2007

机译：X-射线晶体学研究Thermoififida fusca Xeg74催化结构域，人UDP-GlcNAc焦磷酸化酶apo-AGX1和四个葡萄球菌核酸酶突变体以及梭菌胶原酶胶原结合域和S1催化域的结构分析。
6. Soluble guanylate cyclase crystal clear: 1st crystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity [O] . Franziska Seeger, Elsa D Garcin 2013

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7. Soluble guanylate cyclase crystal clear: 1st crystal structure of the wild-type human heterodimeric sGC catalytic domains and implications for activity [O] . Franziska Seeger, Elsa D Garcin 2013

机译：可溶性鸟苷酸环化酶晶体清晰：野生型人异二聚体sGC催化域的第一晶体结构及其对活性的影响

Crystal Structure of the Catalytic Domain of Human ADAM33.

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