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首页> 外文期刊>Journal of Molecular Biology >Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.
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Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.

机译：完整的人类肌节肌球蛋白重链家族的比较序列分析：对功能多样性的影响。

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摘要

The conventional myosin motor proteins that drive mammalian skeletal and cardiac muscle contraction include eight sarcomeric myosin heavy chain (MyHC) isoforms. Six skeletal MyHCs are encoded by genes found in tightly linked clusters on human and mouse chromosomes 17 and 11, respectively. The full coding regions of only two out of six mammalian skeletal MyHCs had been sequenced prior to this work. In an effort to assess the extent of sequence diversity within the human MyHC family we present new full-length coding sequences corresponding to four additional human genes: MyHC-IIb, MyHC-extraocular, MyHC-IIa and MyHC-IIx/d. This represents the first opportunity to compare the full coding sequences of all eight sarcomeric MyHC isoforms within a vertebrate organism. Sequence variability has been analyzed in the context of available structure/function data with an emphasis on potential functional diversity within the family. Results indicate that functional diversity among MyHCs is likely to be accomplished by having small pockets of sequence diversity in an otherwise highly conserved molecule. Copyright 1999 Academic Press.
机译：驱动哺乳动物骨骼和心肌收缩的常规肌球蛋白运动蛋白包括八种肌节肌球蛋白重链（MyHC）亚型。六个骨骼肌MyHCs分别由在人类和小鼠染色体17和11上紧密连接的簇中发现的基因编码。在这项工作之前，已经对六个哺乳动物骨骼MyHC中只有两个的完整编码区进行了测序。为了评估人类MyHC家族内序列多样性的程度，我们提出了与四个其他人类基因相对应的新的全长编码序列：MyHC-IIb，MyHC-exocular，MyHC-IIa和MyHC-IIx / d。这代表了比较脊椎动物生物体内所有八个肌节MyHC同工型的完整编码序列的第一个机会。已经在可用结构/功能数据的背景下分析了序列变异性，重点是该家族中潜在的功能多样性。结果表明，MyHCs之间的功能多样性很可能是通过在其他方面高度保守的分子中保留一小部分序列多样性来实现的。版权所有1999，学术出版社。

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