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首页> 外文期刊>Journal of Molecular Biology >REGULATION OF BCL-2 GENE EXPRESSION BY BCR-ABL IS MEDIATED BY RAS
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REGULATION OF BCL-2 GENE EXPRESSION BY BCR-ABL IS MEDIATED BY RAS

机译：RAS介导BCR-ABL对BCL-2基因表达的调控

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摘要

BCR-ABL is a chimaeric oncogene generated by translocation of sequences from the c-ABL protein-tyrosine kinase gene on chromosome 9 into the BCR gene on chromosome 22. Alternative chimeric proteins, p210(BCR-ABL) and 190(BCR-ABL), are produced that are characteristic of chronic myelogenous leukemia and acute lymphoblastic leukemia, respectively. Their role in the aetiology of human leukemia remains to be defined. We have previously shown that the tumorigenic effect of BCR-ABL oncogenes is mediated by Bcl-2. Ln addition to Bcl-2, is a protein essential for transformation by BCR-ABL. However, it is not known how Bcl-2 and Ras fit together in cell transformation by BCR-ABL. The data presented here establish that Bcl-2 is a downstream target gene of the Ras signalling pathway in cells transformed by BCR-ABL, and that constitutive Ras activation results in constitutive expression of the gene. Conversely, a truncated form of the BCR-ABL, which lacks a critical BCR region required for activation of the Ras signalling pathway, failed to induce Bcl-2 expression. These results indicate that BCR-ABL prevents apoptosis by inducing Bcl-2 through a signalling pathway involving Ras and links constitutive Ras activation and Bcl-2 gene regulation. Hence, these results further imply that Ras is involved in both mitogenic signals and survival signals. (C) 1997 Academic Press Limited. [References: 15]
机译：BCR-ABL是一种嵌合致癌基因，通过将序列从第9号染色体上的c-ABL蛋白-酪氨酸激酶基因转移到第22号染色体上的BCR基因而产生。其他嵌合蛋白p210（BCR-ABL）和190（BCR-ABL）分别产生了慢性粒细胞性白血病和急性淋巴细胞性白血病的特征。它们在人类白血病病因学中的作用尚待确定。先前我们已经表明BCR-ABL致癌基因的致瘤作用是由Bcl-2介导的。除Bcl-2外，Ln是BCR-ABL转化所必需的蛋白质。但是，尚不清楚Bcl-2和Ras如何通过BCR-ABL转化为细胞。此处提供的数据证实Bcl-2是BCR-ABL转化的细胞中Ras信号通路的下游目标基因，并且组成性Ras激活导致该基因的组成型表达。相反，BCR-ABL的截短形式缺少激活Ras信号通路所需的关键BCR区域，但未能诱导Bcl-2表达。这些结果表明，BCR-ABL通过经由涉及Ras的信号传导途径诱导Bcl-2并连接组成性Ras激活和Bcl-2基因调控来阻止凋亡。因此，这些结果进一步暗示Ras参与有丝分裂信号和存活信号。 （C）1997 Academic Press Limited。 [参考：15]

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