Understanding hierarchical protein evolution from first principles [Review]

Dokholyan NV; Shakhnovich EI

首页> 外文期刊>Journal of Molecular Biology >Understanding hierarchical protein evolution from first principles [Review]

【24h】

Understanding hierarchical protein evolution from first principles [Review]

机译：从首要原理了解蛋白质的分层进化[综述]

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We propose a model that explains the hierarchical organization of proteins in fold families. The model, which is based on the evolutionary selection of proteins by their native state stability, reproduces patterns of amino acids conserved across protein families. Due to its dynamic nature, the model sheds light on the evolutionary time-scales. By studying the relaxation of the correlation function between consecutive mutations at a given position in proteins, we observe separation of the evolutionary time-scales: at short time intervals families of proteins with similar sequences and structures are formed, while at long time intervals the families of structurally similar proteins that have low sequence similarity are formed. We discuss the evolutionary implications of our model. We provide a "profile" solution to our model and find agreement between predicted patterns of conserved amino acids and those actually observed in nature.

机译：我们提出了一个模型，该模型解释了折叠家族中蛋白质的层次结构。该模型基于通过蛋白质的天然状态稳定性对蛋白质进行进化选择，从而重现了跨蛋白质家族保守的氨基酸模式。由于其动态性质，该模型为演化时间尺度提供了启示。通过研究蛋白质给定位置上连续突变之间相关性函数的松弛，我们观察到进化时间尺度的分离：在短时间间隔内形成具有相似序列和结构的蛋白质家族，而在长时间间隔内形成家族形成具有低序列相似性的结构相似的蛋白质。我们讨论了模型的进化含义。我们为模型提供了一个“轮廓”解决方案，并发现了保守氨基酸的预测模式与自然界中实际观察到的模式之间的一致性。

著录项

来源
《Journal of Molecular Biology》 |2001年第1期|共19页
作者
Dokholyan NV; Shakhnovich EI;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
Protein evolution; Energy gap model; Profile solution; Amino-acid-sequences; Random energy-model; Statistical-mechanics; Transition-state; Folding nucleus; 3-dimensional structure; Foldability; landscape; Molecular-dynamics; Chey; Thermodynamics;

机译：蛋白质进化;能隙模型;轮廓解;氨基酸序列;随机能模型;统计力学;过渡态;折叠核;三维结构;可折叠性;景观;分子动力学;Chey;热力学;

相似文献

外文文献
中文文献
专利

1. Understanding hierarchical protein evolution from first principles [Review] [J] . Dokholyan NV, Shakhnovich EI Journal of Molecular Biology . 2001,第1期

机译：从首要原理了解蛋白质的分层进化[综述]
2. Formation and evolution of a self-organized hierarchy of Ge nanostructures on Si(111)-(7X7): STM observations and first-principles calculations [J] . H. F. Ma, Z. H. Qin, M. C. Xu, Physical review. B, Condensed Matter And Materials Physics . 2007,第16期

机译：Si（111）-（7X7）上Ge纳米结构自组织层次的形成和演化：STM观察和第一性原理计算
3. Formation and evolution of a self-organized hierarchy of Ge nanostructures on Si(111)-(7 × 7):STM observations and first-principles calculations [J] . H. F. Ma, Z. H. Qin, M. C. Xu, Physical review . 2007,第16期

机译：Si（111）-（7×7）上Ge纳米结构自组织层次的形成和演化：STM观察和第一性原理计算
4. Towards an understanding of protein-protein interaction network hierarchies. Analysis of DnaN (β)-binding peptide motifs in members of protein families interacting with the eubacterial processivity clamp, the β subunit of DNA Polymerase III [C] . Brian P. Dalrymple, Gene Wijffels, Kritaya Kongsuwan, Asia-Pacific Bioinformatics Conference(APBC 2003); 200302; Adelaide(AU) . 2003

机译：对蛋白质-蛋白质相互作用网络层次结构的理解。蛋白质家族成员与DNA聚合酶III的优生过程性钳位相互作用的DnaN（β）结合肽基序分析
5. Understanding structure, function and evolution of protein-protein interactions by computational modeling and analysis. [D] . Zhao, Nan. 2013

机译：通过计算建模和分析了解蛋白质相互作用的结构，功能和进化。
6. Superhydrophobic hierarchically structured surfaces in biology: evolution structural principles and biomimetic applications [O] . W. Barthlott, M. Mail, C. Neinhuis -1

机译：生物学中的超疏水分层结构表面：进化结构原理和仿生应用
7. Understanding hierarchical protein evolution from first principles [O] . Nikolay V. Dokholyan, Eugene I. Shakhnovich 2001

机译：从第一原理理解分层蛋白质的进化

Understanding hierarchical protein evolution from first principles [Review]

摘要

著录项

相似文献

相关主题

期刊订阅