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首页> 外文期刊>Journal of Molecular Biology >Birth of a gene: Locus of neuronal BC200 snmRNA in three prosimians and human BC200 pseudogenes as archives of change in the Anthropoidea lineage
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Birth of a gene: Locus of neuronal BC200 snmRNA in three prosimians and human BC200 pseudogenes as archives of change in the Anthropoidea lineage

机译：基因的诞生：三个猿猴中的神经元BC200 snmRNA的基因座和人类BC200假基因，作为拟人猿谱系变化的档案

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The gene encoding brain-specific dendritic BC200 small non-messenger RNA is limited to the primate order and arose from a monomeric Alu element. It is present and neuronally expressed in all Anthropoiden examined. By comparing the human sequence of about 13.2 kb with each of the prosimian (lemur 14.6 kb, galago 12 kb, and tarsier 13.8 kb) orthologous loci, we could establish that the BC200 RNA gene is absent from the prosimian lineages. In Strepsirhini (lemurs and lorises), a dimeric AluJ-like element integrated Very close to the BC; while the corresponding tarsier region is devoid of any repetitive element. Consequently, insertion of the Alu monomer that gave rise to the BC200 RNA gene must have occurred after the anthropoid lineage diverged from the prosimian lineage(s). Shared insertions of other repetitive elements favor proximity of simians and tarsiers in support of their grouping into Haplorhini and the omomyid hypothesis. On the other hand, the nucleotide sequences in the segment that is available for comparison in all four species reveal less exchanges between Strepsirhini (lemur and galago) and human than between tarsier and human. Our data imply that the early activity of dimeric Alu sequences must have been concurrent with the activity of monomeric Alu elements that persisted longer than is usually thought. As BC200 RNA gave rise to more than 200 pseudogenes, we used their consensus sequence variations as a molecular archive recording the BC200 RNA sequence changes in the anthropoid lineage leading to Homo sapiens and timed these alterations over the past 35-55 million years. (C) 2001 Academic Press. [References: 75]
机译：编码脑特异性树突状BC200小非信使RNA的基因仅限于灵长类动物，由单体Alu元件产生。它存在于所有拟人猿中并在神经元中表达。通过比较大约13.2 kb的人类序列与每个Prosimian直系同源位点（lemur 14.6 kb，galago 12 kb和tarsier 13.8 kb），我们可以确定BC200 RNA基因不存在于Prosimian谱系中。在链霉菌属（Strepsirhini）中（lemurs和lorises），一个二聚体的AluJ样元件非常靠近BC整合;而相应的眼镜猴区域则没有任何重复元素。因此，必须在类人猿谱系从一个或多个猿猴谱系中分离出之后，才产生了引起BC200 RNA基因的Alu单体。其他重复元素的共同插入有利于猿猴和眼镜猴的接近，以支持将它们分为Haplorhini和omomyid假说。另一方面，可用于所有四个物种进行比较的片段中的核苷酸序列显示链霉菌属（lemur和galago）与人之间的交换比眼镜猴与人之间的交换少。我们的数据表明，二聚体Alu序列的早期活性必须与持续比通常认为更长的单体Alu元素的活性同时存在。由于BC200 RNA产生了200多个假基因，我们将它们的共有序列变异用作分子档案，记录了导致人智的类人猿谱系中BC200 RNA序列的变化，并在过去的35-5500万年中对这些变化进行了计时。 （C）2001学术出版社。 [参考：75]

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