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首页> 外文期刊>Journal of Materials Chemistry, B. materials for biology and medicine >pH-controlled delivery of curcumin from a compartmentalized solid lipid nanoparticle@mesostructured silica matrix
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pH-controlled delivery of curcumin from a compartmentalized solid lipid nanoparticle@mesostructured silica matrix

机译:从间隔化的固体脂质纳米颗粒@介观结构的二氧化硅基质中pH调节姜黄素的递送

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摘要

Silicalization of curcumin-loaded solid lipid nanoparticle (SLN)/micelle dispersions afforded a compartmentalized nanovector, with both macro-and mesostructured domains. SLNs act as reservoirs of curcumin (CU), while mesopores act as pathways to control drug release. Moreover, the release sustainability depends on the nature of the solid lipid (cetyl palmitate vs. stearic acid) and on the pH of the receiving phase. The meso-macrostructured silica matrix templated by SLNs appears thus as a promising drug delivery system for pH-responsive controlled release.
机译:姜黄素负载的固体脂质纳米颗粒(SLN)/胶束分散体的硅化处理提供了具有宏观结构域和介观结构域的间隔化纳米载体。 SLN充当姜黄素(CU)的储库,而中孔充当控制药物释放的途径。此外,释放的可持续性取决于固体脂质的性质(棕榈酸鲸蜡基酯对硬脂酸)和接收相的pH值。因此,由SLNs模板化的中微结构二氧化硅基质似乎是有希望的pH响应控释药物输送系统。

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