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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Effects of the local anesthetic benzocaine on the human erythrocyte membrane and molecular models.
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Effects of the local anesthetic benzocaine on the human erythrocyte membrane and molecular models.

机译：局麻药苯佐卡因对人红细胞膜和分子模型的影响。

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摘要

The interaction of the local anesthetic benzocaine with the human erythrocyte membrane and molecular models is described. The latter consisted of isolated unsealed human erythrocyte membranes (IUM), large unilamellar vesicles (LUV) of dimyristoylphospatidylcholine (DMPC), and phospholipid multilayers of DMPC and dimyristoylphospatidyletanolamine (DMPE), representatives of phospholipid classes located in the outer and inner monolayers of the human erythrocyte membrane, respectively. Optical and scanning electron microscopy of human erythrocytes revealed that benzocaine induced the formation of echinocytes. Experiments performed on IUM and DMPC LUV by fluorescence spectroscopy showed that benzocaine interacted with the phospholipid bilayer polar groups and hydrophobic acyl chains. X-ray diffraction analysis of DMPC confirmed these results and showed that benzocaine had no effects on DMPE. The effect on sodium transport was also studied using the isolated toad skin. Electrophysiological measurements indicated a significant decrease in the potential difference (PD) and in the short-circuit current (Isc) after the application of benzocaine, reflecting inhibition of active ion transport.
机译：描述了局部麻醉剂苯佐卡因与人红细胞膜和分子模型的相互作用。后者由孤立的未密封的人红细胞膜（IUM），二豆蔻酰磷脂酰胆碱（DMPC）的大单层囊泡（LUV）以及DMPC和二豆蔻酰磷脂酰乙醇胺（DMPE）的磷脂多层组成，磷脂类的代表位于人的外单层和内单层红细胞膜。人体红细胞的光学和扫描电子显微镜显示，苯佐卡因诱导了棘突细胞的形成。通过荧光光谱法对IUM和DMPC LUV进行的实验表明，苯佐卡因与磷脂双层极性基团和疏水性酰基链相互作用。 DMPC的X射线衍射分析证实了这些结果，并表明苯佐卡因对DMPE没有影响。还使用分离的蟾蜍皮研究了对钠运输的影响。电生理学测量表明，应用苯佐卡因后电势差（PD）和短路电流（Isc）显着降低，反映出对活性离子迁移的抑制。

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