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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Structural insight into the interactions of SoxV, SoxW and SoxS in the process of transport of reductants during sulfur oxidation by the novel global sulfur oxidation reaction cycle.
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Structural insight into the interactions of SoxV, SoxW and SoxS in the process of transport of reductants during sulfur oxidation by the novel global sulfur oxidation reaction cycle.

机译：通过新颖的整体硫氧化反应循环，深入了解SoxV，SoxW和SoxS在硫氧化过程中的还原剂运输过程中的相互作用。

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摘要

Microbial redox reactions involving inorganic sulfur compounds, mainly the sulfur anions, are one of the vital reactions responsible for the environmental sulfur balance. These reactions are mediated by phylogenetically diverse prokaryotes, some of which also take part in the extraction of metal ions from their sulfur containing ores. These sulfur oxidizers oxidize inorganic sulfur compounds like sulfide, thiosulfate etc. to produce reductants that are used for carbon dioxide fixation or in respiratory electron transfer chains. The sulfur oxidizing gene cluster (sox) of alpha-Proteobacteria comprises of at least 15 genes, forming two transcriptional units, viz., soxSR and soxVWXYZABCDEFGH. SoxV is known to be a CcdA homolog involved in the transport of reductants from cytoplasm to periplasm. SoxW and SoxS are periplasmic thioredoxins, which (SoxW) interact with SoxV and thereby help in the redox reactions. We have employed homology modeling to construct the three-dimensional structures of the SoxV, SoxW and SoxS proteins from Rhodovulum sulfidophilum. With the help of docking and molecular dynamics simulations we have identified the amino acid residues of these proteins involved in the interaction. The probable biochemical mechanism of the transport of reductants through the interactions of these proteins has also been investigated. Our study provides a rational basis to interpret the molecular mechanism of the biochemistry of sulfur anion oxidation reactions by these ecologically important organisms.
机译：涉及无机硫化合物（主要是硫阴离子）的微生物氧化还原反应是导致环境中硫平衡的重要反应之一。这些反应是由系统发育多样的原核生物介导的，其中一些还参与从含硫矿石中提取金属离​​子。这些硫氧化剂氧化无机硫化合物，例如硫化物，硫代硫酸盐等，以生成用于二氧化碳固定或呼吸电子转移链的还原剂。 α-变形杆菌的硫氧化基因簇（sox）包含至少15个基因，形成两个转录单位，即soxSR和soxVWXYZABCDEFGH。已知SoxV是一种CcdA同源物，参与了还原剂从细胞质到周质的转运。 SoxW和SoxS是周质硫氧还蛋白，它们（SoxW）与SoxV相互作用，从而有助于氧化还原反应。我们已采用同源性建模来构建从嗜硫红球菌SoxV，SoxW和SoxS蛋白的三维结构。借助对接和分子动力学模拟，我们已经确定了参与相互作用的这些蛋白质的氨基酸残基。还研究了通过这些蛋白质的相互作用运输还原剂的可能的生化机理。我们的研究为解释这些具有生态学意义的生物进行硫阴离子氧化反应的生物化学的分子机理提供了合理的基础。

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