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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Stochastic transcription initiation: Time dependent transcription rates
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Stochastic transcription initiation: Time dependent transcription rates

机译：随机转录起始：时间依赖性转录速率

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摘要

The noise in the central process such as transcription, replication and translation of the genomic DNA is very important since it can directly affect the phenotypic and behavioral aspects of an organism as well as the entire cellular function. Here we develop a model on the transcription process based on the assumption that the initiation of the transcription is a stochastic event and the transcription rates may be time dependent random quantities. We derive the central measure properties i.e. mean and the variance, of the distribution of the transcription rates. Our results show that the Fano factor which is a measure of deviation from the Poisson distribution associated with the fluctuations in the number of mRNA molecules deviates from unity due to the randomness in the transcription rates. However when the RNA polymerase molecule searches for the promoter sequences on the DNA lattice by random jumps, the Fano factor approaches the Poisson limit as the jump size associated with the RNA polymerase increases. Since the jump size associated with dynamics of RNAP molecule is positively correlated with the degree of super coiling of DNA, we argue that the super coiled or close-packed structure of DNA might have evolved to keep the noises at the transcriptional level in a minimum. (c) 2006 Elsevier B.V. All rights reserved.
机译：中心过程中的噪音（例如基因组DNA的转录，复制和翻译）非常重要，因为它会直接影响生物体的表型和行为方面以及整个细胞功能。在这里，我们基于转录的起始是随机事件并且转录速率可能是时间依赖的随机量的假设，开发了一个有关转录过程的模型。我们得出了转录速率分布的中心度量属性，即均值和方差。我们的结果表明，由于转录速率的随机性，Fano因子是与Poisson分布偏差的度量，该偏差与mRNA分子数量的波动相关联。但是，当RNA聚合酶分子通过随机跳跃在DNA晶格上搜索启动子序列时，随着与RNA聚合酶相关的跳跃大小增加，Fano因子接近泊松极限。由于与RNAP分子动力学相关的跳跃大小与DNA的超卷曲程度呈正相关，因此我们认为DNA的超卷曲或紧密堆积结构可能已经进化为将噪音保持在转录水平最低。 （c）2006 Elsevier B.V.保留所有权利。

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