A revisit to the one form kinetic model of prothrombinase.

Lee CJ; Wu S; Eun C; Pedersen LG

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A revisit to the one form kinetic model of prothrombinase.

机译：回顾凝血酶原的一种形式的动力学模型。

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Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles from two independent groups for these two pathways have been re-analyzed. By rationally combining the independent data sets, a simple mechanism can be established and rate constants determined. A structural model is consistent with the data-derived finding that mechanisms that feature channeling or ratcheting are not necessary to describe thrombin production.

机译：凝血酶是通过凝血酶原和凝血酶原2的两个途径从凝血酶原酶促地产生的。来自这两个途径的两个独立组的实验浓度分布已经重新分析。通过合理地组合独立数据集，可以建立一种简单的机制并确定速率常数。结构模型与数据衍生的发现相一致，即发现形成凝血酶的机制不一定具有特征化通道或棘齿的机制。

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2010年第2期|共6页
作者
Lee CJ; Wu S; Eun C; Pedersen LG;
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正文语种 eng
中图分类生物化学;生物物理学;
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1. A revisit to the one form kinetic model of prothrombinase. [J] . Lee CJ, Wu S, Eun C, Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2010,第1a2期

机译：回顾凝血酶原的一种形式的动力学模型。
2. A revisit to the one-form kinetic model of prothrombinase: A comment on the rebuttal [J] . Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2012,第1期

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3. A revisit of the two-form kinetic model of prothrombinase: A rebuttal [J] . Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2012,第1期

机译：凝血酶原的两种形式的动力学模型的回顾：一个反驳
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6. A Revisit to the One Form Kinetic Model of Prothrombinase [O] . Chang Jun Lee, Sangwook Wu, Changsun Eun, -1

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A revisit to the one form kinetic model of prothrombinase.

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