...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of natural toxins >Comparison of the lethal components in Vipera aspis aspis and Vipera aspis zinnikeri venom.
【24h】

Comparison of the lethal components in Vipera aspis aspis and Vipera aspis zinnikeri venom.

机译：毒蛇and和毒蛇毒的致死成分比较。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Biological activities in Vipera a. aspis and V. a. zinnikeri venom were investigated and compared. Phospholipase A2 and lethal activities were found to be much higher in V. a. zinnikeri venom; the LD50 values for V. a. aspis and V. a. zinnikeri crude venom were 0.55 and 0.35 microgram/g, while PLA2 activities were 25.4 and 41.8 unit/mg, respectively. Other enzymatic and pharmacological activities investigated were similar in both venoms, suggesting that PLA2s might be responsible for the higher toxicity of V. a. zinnikeri venom. PLA2s contained in both venoms were compared immunologically, and the highly lethal phospholipase A2 (PLA2-I) purified from V. a. zinnikeri venom was not found in V. a. aspis venom as determined by antiserum for purified PLA2-I. The toxic effect of V. a. zinnikeri venom was inhibited by anti-PLA2-I, while the same antiserum could not prevent lethality by V. a. aspis venom. These results indicate that PLA2-I in V. a. zinnikeri venom possesses an important role in the lethal activity of this venom. Although V. a. zinnikeri is found in a defined area of France, it is possible that its lethal venom component developed differently than that of V. a. aspis.
机译：Vi蛇的生物活动aspis和V. zinnikeri毒液进行了调查和比较。发现V. a。中的磷脂酶A2和致死活性要高得多。 zinnikeri毒液; V的LD50值。 aspis和V. zinnikeri粗毒液分别为0.55和0.35微克/克，而PLA2活性分别为25.4和41.8单位/毫克。研究的其他酶和药理活性在两种毒液中都相似，表明PLA2s可能是大肠弧菌较高的毒性的原因。津尼克里毒液。对两种毒液中包含的PLA2s进行了免疫学比较，并从大叶黄精中纯化了高度致死性的磷脂酶A2（PLA2-I）。在V. a。中找不到zinnikeri毒液。用抗血清测定纯化的PLA2-I的毒气。 V. a。的毒性作用。 Zinnikeri毒液被抗PLA2-I抑制，而相同的抗血清不能阻止V. a。的致死性。阿斯皮毒液。这些结果表明V2-a中的PLA2-I。 zinnikeri毒液在这种毒液的致死活动中具有重要作用。虽然V. zinnikeri在法国的特定地区发现，其致命的毒液成分可能不同于V. a.。阿斯皮斯

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号