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首页> 外文期刊>Journal of natural toxins >Pathophysiological effects of Russell's viper venom on renal function.
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Pathophysiological effects of Russell's viper venom on renal function.

机译：罗素毒蛇毒对肾脏功能的病理生理影响。

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摘要

Pathophysiological effects of Russell's viper venom (RVV) on renal function are reviewed. The evidence in experimental animals on the mechanisms of venom action in relation to changes in either extrarenal or intrarenal factors is considered. The cardiovascular system and renal hemodynamics are affected by the venom. Mean arterial blood pressure, heart rate, cardiac output, and renal hemodynamics decrease, while total peripheral vascular resistance and renal vascular resistance increase in the initial post-injection period of envenoming. After the transitory decrease, all parameters for general circulation gradually increase, returning to near normal level within 30 min, while an increase in renal vascular resistance and decreases in renal blood flow and glomerular filtration rate are still apparent 48 h after envenomation. The effects of venom on renal vasoconstriction are discussed. Possible factors, especially humoral factors, inducing these changes are considered. Russell's viper venom is also able to affect renal tubular cells directly. This can be explained based on available data from in vitro studies. Different studies have been performed to investigate venom action in the isolated perfused kidney, changes in the characteristic polarization of the cell membrane, changes in mitochondria activity and changes in Na, K-ATPase activity of the tissue of both the renal cortex and medulla during envenomation.
机译：综述了罗素毒蛇毒（RVV）对肾功能的病理生理影响。考虑到实验动物中有关肾外或肾内因素变化的毒液作用机制的证据。心血管系统和肾脏血液动力学受毒液影响。在注入毒液的最初阶段，平均动脉血压，心率，心输出量和肾脏血液动力学降低，而总外周血管阻力和肾血管阻力增加。短暂减少后，一般循环的所有参数逐渐增加，在30分钟内恢复到接近正常水平，而在麻醉后48小时，肾血管阻力增加，肾血流量和肾小球滤过率降低仍很明显。讨论了毒液对肾血管收缩的影响。考虑了引起这些变化的可能因素，尤其是体液因素。罗素的毒蛇毒液也能够直接影响肾小管细胞。可以根据体外研究的可用数据进行解释。已经进行了不同的研究来研究毒液在离体灌注肾脏中的毒液作用，细胞膜特征极化的变化，线粒体活性的变化以及在麻醉过程中肾皮质和髓质组织的Na，K-ATPase活性的变化。 。

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