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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Flexible loops of thread-like micelles are formed upon interaction of L-alpha-dimyristoyl-phosphatidylcholine with the biosurfactant surfactin as revealed by cryo-electron tomography.
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Flexible loops of thread-like micelles are formed upon interaction of L-alpha-dimyristoyl-phosphatidylcholine with the biosurfactant surfactin as revealed by cryo-electron tomography.

机译：L-α-二肉豆蔻酰基-磷脂酰胆碱与生物表面活性剂表面活性素的相互作用会形成线状胶束的柔性环，如低温电子层析成像所揭示。

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摘要

Vesicles of L-alpha-dimyristoyl-phosphatidylcholine (DMPC) are known to disintegrate upon treatment with surfactin, a lipoheptapeptide biosurfactant from Bacillus subtilis OKB 105, as was observed by static light scattering (SLS) and cryo-transmission electron microscopy (cryo-TEM) recently. The lysis of DMPC bilayers occurs strongly dependent on the surfactin concentration according to a three-stage model. Unilamellar DMPC vesicles are disrupted to form sheet-like lamellar intermediates at a moderate surfactant concentration, but undergo a transition towards smaller particles of unknown structure at a higher surfactant concentration according to earlier neutron scattering experiments. Here we present direct structural evidence from cryo-electron tomography data that thread-like micelles with a uniform diameter of 6.5 nm are organized into loops of different sizes at a surfactin concentration of > 15 mol%.
机译：已知L-α-二肉豆蔻酰基磷脂酰胆碱（DMPC）的囊泡在表面活性剂（一种来自枯草芽孢杆菌OKB 105的脂肽肽生物表面活性剂）处理后会分解，如通过静态光散射（SLS）和低温透射电子显微镜（cryo-TEM）所观察到的） 最近。根据三阶段模型，DMPC双层的溶解强烈取决于表面活性素的浓度。根据较早的中子散射实验，单层DMPC囊泡在中等表面活性剂浓度下破裂形成片状层状中间体，但在较高表面活性剂浓度下却向未知结构的较小颗粒过渡。在这里，我们从冷冻电子层析成像数据中获得直接的结构证据，表明表面活性剂浓度> 15 mol％时，均匀直径为6.5 nm的线状胶束组织成不同大小的环。

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