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首页> 外文期刊>Journal of natural toxins >Cross neutralization of dangerous snake venoms from Africa and the Middle East using the VACSERA polyvalent antivenom. Egyptian Organization for Biological Products & Vaccines.
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Cross neutralization of dangerous snake venoms from Africa and the Middle East using the VACSERA polyvalent antivenom. Egyptian Organization for Biological Products & Vaccines.

机译：使用VACSERA多价抗蛇毒血清交叉中和来自非洲和中东的危险蛇毒。埃及生物制品和疫苗组织。

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摘要

This study was performed to assess the ability of polyvalent snake venom anti-serum, produced by the Egyptian Organization for Biological Products & Vaccines (VACSERA), to neutralize several toxic activities of snake venoms, not only of those included in the antivenom mixture, but also some additional venoms of snakes from Egyptian, African, and Middle Eastern habitats. In general, the results revealed that polyvalent snake venom anti-serum from VACSERA is highly effective in neutralizing Egyptian snake venoms, especially Naja haje, Naja nigricolles, Naja pallida, Cerastes cerastes, Cerastes cerastes cerastes, Cerastes vipera, Pseudocerastes persicus fieldi, and Walterinnisia egyptia. The antivenom was also effective against Naja haje, Walterinnisia egyptia, and Bites aritans from Saudi Arabia. High activity was obtained against venoms from Naja haje, Naja nigricolles, and Naja pallida of Sudan, as well as the African Naja melanoleuca, Naja mossambica, Naja naja oxiana, Bites gabonica, and Vipera lebetina. Only moderate effectiveness was obtained with Echis coloratus and Echis carinatus, and the polyvalent antiserum was ineffective against the venom of Naja nivea.
机译：这项研究的目的是评估埃及生物产品和疫苗组织（VACSERA）生产的多价蛇毒抗血清中和蛇毒的几种毒性的能力，不仅包括抗蛇毒混合物中的那些，而且包括还有来自埃及，非洲和中东栖息地的蛇的其他毒液。总的来说，该结果表明VACSERA的多价蛇毒抗血清在中和埃及蛇毒方面非常有效，尤其是中毒眼镜蛇（Naja haje），中毒眼镜蛇（Nija nigricolles），中毒眼镜蛇（Naja pallida），Cerastes cerastes，Cerastes cerastes cerastes，Cerastes vipera，Pseudocerastes persicus fieldi，埃及。该抗蛇毒药还可以有效对抗来自沙特阿拉伯的眼镜蛇（Naja haje），埃及沃尔特林尼西亚（Walterinnisia）和阿里斯坦人（Bites aritans）。苏丹的Naja haje，Naja nigricolles和Naja pallida以及非洲的Naja melanoleuca，Naja mossambica，Naja naja oxiana，Bites gabonica和Vipera lebetina获得了针对蛇毒的高活性。七叶E和七叶E仅获得中等效力，而多价抗血清对娜雅的毒液无效。

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