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首页> 外文期刊>Journal of natural toxins >Pharmacological actions of nerve growth factor-transferrin conjugate on the central nervous system.
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Pharmacological actions of nerve growth factor-transferrin conjugate on the central nervous system.

机译：神经生长因子-转铁蛋白结合物对中枢神经系统的药理作用。

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摘要

Transferrin (Tf) undergoes receptor-mediated transport through the blood-brain barrier in vivo. This property allows transferrin to act as a vector for drug transport to the brain. The present investigation examines both the profile of brain delivery of nerve growth factor (NGF)-transferrin conjugate, and its therapeutic effects on CNS neurodegeneration, which affect locomotion and memory. Delivery of NGF-Tf conjugate to the brain was measured and found to be 0.075% of the injected dose per gram of brain, which is 5-fold higher than that of biotin-NGF. The increased delivery using the NGF-Tf conjugate can be attributed to an increased BBB permeability surface area product, which is about 8-fold higher than that of biotin-NGF. Intravenous injection of biotin-NGF/Tf-avidin conjugate significantly increased neuronal survival in the substantia nigra of a Parkinson's disease mouse model. In addition, this conjugate also improved recognition and memory in Alzheimer's disease rat model. In summary, these results demonstrate that using transferrin as a delivery vector is effective in targeting NGF to the central nervous system (CNS), and may optimize the therapy of age-related neurodegenerative diseases.
机译：转铁蛋白（Tf）在体内通过血脑屏障进行受体介导的转运。这一特性使转铁蛋白可作为药物转运到大脑的载体。本研究同时检查了神经生长因子（NGF）-转铁蛋白偶联物的脑部输送情况及其对中枢神经系统神经退行性疾病的治疗作用，后者影响运动和记忆。测量了NGF-Tf偶联物向大脑的递送，发现是每克大脑注射剂量的0.075％，比生物素-NGF高5倍。使用NGF-Tf共轭物的递送增加可归因于BBB渗透性表面积产物的增加，其比生物素-NGF的表面积约高8倍。静脉注射生物素-NGF / Tf-抗生物素蛋白偶联物可显着提高帕金森氏病小鼠模型黑质中神经元的存活率。另外，该缀合物还改善了阿尔茨海默氏病大鼠模型的识别和记忆。总之，这些结果表明，使用转铁蛋白作为递送载体可以有效地将NGF靶向中枢神经系统（CNS），并且可以优化与年龄有关的神经退行性疾病的治疗。

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