...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of natural toxins >Restoration of nerve growth factor in organs of mice injected with cobra venom followed by specific treatment and reversal period.
【24h】

Restoration of nerve growth factor in organs of mice injected with cobra venom followed by specific treatment and reversal period.

机译：注射眼镜蛇毒的小鼠器官中神经生长因子的恢复，然后进行特定治疗和逆转期。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Research from this laboratory reported the decreased levels of endogenously present nerve growth factor (NGF) in organs of mice as a consequence of sub-lethal injection of Naja kaouthia venom. This research reports that the decreased levels of NGF in organs of mice were prevented by (1) specific treatment and (2) restored to normal by a prolonged period. Adult female Balb/c mice were injected intramuscularly (IM) with a sub-lethal dose of cobra venom. The injected mice were divided into five groups. Mice in group I were injected with PBS, group II with anti-cobra venom, and group III with lethal toxin neutralizing factor (LTNF). Mice in group IV were treated IM with synthetic LTNF (LT-10), and mice in group V were treated orally with LT-10. After 24 hr. mice were sacrificed and NGF levels in organ homogenates were assayed and compared with control mice not injected with venom. It was observed that the organs from group I treated with PBS showed a tremendous drop in NGF level in comparison to the organs of the control mice. It was further revealed that the decreased levels of NGF in organs of injected mice were prevented by treatment with anti-cobra venom, LTNF and LT-10 by IM, or oral routes. In the second series of experiments, mice injected with sub-lethal dose of cobra venom were sacrificed after 1, 3, 7, and 10 days, and the organs were assayed for NGF levels. It was observed that the recovery period for normal homeostasis of NGF was between 7 and 10 days in the brain, heart, liver, salivary glands, and ovaries.
机译：来自该实验室的研究报告称，由于亚致命性的毒眼镜蛇毒液的注射，小鼠器官中内源性神经生长因子（NGF）的含量降低。这项研究报告指出，通过（1）特异性治疗可预防小鼠器官中NGF含量的降低，并且（2）可以长期延长其恢复正常水平。成年雌性Balb / c小鼠肌肉注射（IM）亚致死剂量的眼镜蛇毒。注射的小鼠分为五组。第一组小鼠注射PBS，第二组注射抗眼镜蛇毒，第三组注射致命毒素中和因子（LTNF）。 IV组的小鼠接受了合成LTNF（LT-10）的IM治疗，V组的小鼠接受了LT-10的口服治疗。 24小时后。处死小鼠，测定器官匀浆中的NGF水平，并与未注射毒液的对照小鼠进行比较。观察到，与对照小鼠的器官相比，用PBS处理的I组的器官显示出NGF水平的极大降低。进一步揭示，通过IM或口服途径用抗眼镜蛇毒，LTNF和LT-10治疗可防止注射的小鼠器官中NGF水平降低。在第二系列实验中，在注射第1天，第3天，第7天和第10天后，将注射了亚致死剂量的眼镜蛇毒的小鼠处死，并测定其器官的NGF水平。观察到，在脑，心脏，肝脏，唾液腺和卵巢中，NGF正常稳态的恢复期为7至10天。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号