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首页> 外文期刊>Journal of natural toxins >Biological activities of the crude skin toxin of the Suez Gulf oriental catfish (Plotosus lineatus) and its antitumor effect in vivo (mice).
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Biological activities of the crude skin toxin of the Suez Gulf oriental catfish (Plotosus lineatus) and its antitumor effect in vivo (mice).

机译：苏伊士湾东方cat鱼（Plotosus lineatus）的粗皮毒素的生物活性及其在体内的抗肿瘤作用（小鼠）。

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Quantitative determination of newly reported enzymes activity in the crude skin toxin (CST) of catfish revealed highest activities of hyaluronidase and lipase, lesser activities of phospholipase A2, lactate dehydrogenase (LDH), cholinesterase (CE), alkaline phosphatase (ALP), and aspartate transaminase (AST), and least activities of proteinase and 5-nucleotidase (5'-NT). The CST has a hemolytic activity of 54% and no ichthyotoxicity up to 500 ug/ml. The chosen dose of CST (LD12.5) showed a potential cytotoxic activity against solid Ehrlich carcinoma-bearing mice demonstrated by an increase in the mean survival time (238.8%) and tumor growth inhibition ratio (T/C) of 73%. The CST ameliorated the relative weights of heart and liver after three weeks, while modulating the elevation in the relative spleen weight throughout the treatment periods (three, six, and nine weeks). The levels of serum triglyceride, total cholesterol, and liver total lipids were normalized after three weeks, whereas the serum albumin and hepatic glycogen concentrations, as well as ALT, AST, 5'-NT, and G-6-Pase activities were ameliorated after 6 weeks. Serum levels of glucose, LDH, and creatine kinase (CK) activities were significantly modulated throughout the treatment periods. Histological examinations of the tumor and liver tissues of treated tumor-bearing animals were carried out. Tumor tissues showed many cytolytic and cytopathic changes after treatment, while liver tissues showed moderate dysplastic changes after six weeks of treatment, which became more marked after nine weeks.
机译：对reported鱼粗皮毒素（CST）中新报告的酶活性进行定量测定表明，透明质酸酶和脂肪酶的活性最高，磷脂酶A2，乳酸脱氢酶（LDH），胆碱酯酶（CE），碱性磷酸酶（ALP）和天冬氨酸的活性较低转氨酶（AST），以及最小的蛋白酶和5-核苷酸酶（5'-NT）活性。 CST的溶血活性为54％，至500 ug / ml时无鱼鳞毒素。选择的CST剂量（LD12.5）对平均携带艾氏癌的小鼠具有潜在的细胞毒性活性，这是通过平均存活时间（238.8％）和肿瘤生长抑制率（T / C）增加73％来证明的。三周后，CST改善了心脏和肝脏的相对重量，同时在整个治疗期间（三，六和九周）调节了相对脾脏重量的升高。三周后血清甘油三酸酯，总胆固醇和肝脏总脂质水平恢复正常，而血清白蛋白和肝糖原浓度以及ALT，AST，5'-NT和G-6-Pase活性得到改善。 6个星期在整个治疗期间，血清中的葡萄糖，LDH和肌酸激酶（CK）活性显着调节。对所治疗的荷瘤动物的肿瘤和肝组织进行组织学检查。治疗后肿瘤组织表现出许多溶细胞性和细胞病变性变化，而治疗六周后肝组织显示中度异常增生性变化，在九周后变得更加明显。

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