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首页> 外文期刊>Journal of natural toxins >Renal function following sea snake venom (Lapemis hardwicki) administration in dogs treated with sodium bicarbonate solution.
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Renal function following sea snake venom (Lapemis hardwicki) administration in dogs treated with sodium bicarbonate solution.

机译：在用碳酸氢钠溶液治疗的狗中施用海蛇毒（Lapemis hardwicki）后的肾功能。

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The effects of sea snake venom (SSV) on renal function were studied in two groups of anesthetized experimental dogs pretreated with intravenous infusion of 4.2 gm% NaHCO3 solution. Animals were envenomated by intramuscular injection of SSV at a dosage of 0.34 mg/kg. Systemic hemodynamics showed no significant changes except for a tendency of decrease in cardiac output (CO). The glomerular filtration rate (GFR), the rate of urine flow (V) and effective renal plasma flow (ERPF), and effective renal blood flow (ERBF) significantly decreased, while filtration fraction (FF) significantly increased at 180 min after envenomation. Envenomated animals showed a reduction in renal fraction (RF), while renal vascular resistance (RVR) increased stepwise throughout the experimental periods. Animals pretreated with sodium bicarbonate showed no significant changes of CO, TPR MAP, HR, and packed cell volume (PCV) while receiving sea snake venom. Animals pretreated with sodium bicarbonate showed no changes in GFR, ERPF, ERBF, RF, and RVR after envenomation. The rate of urine flow markedly increased in envenomated animals which received pretreatment with bicarbonate. After envenomation alone, there were no differences in the plasma concentration of sodium (PNa) and chloride (PCl) as compared to the control value, whereas the plasma concentration of potassium (PK) increased at 180 min after envenomation. Animals pre-treated with bicarbonate showed a stepwise increase in both UNaV, FE(NA), U(Cl)V, and FE(Cl) accompanying SSV injection. Neither PNa nor PCl were affected, while PK significantly decreased in animals given SSV with bicarbonate loading. UKV and FEK increased stepwise in envenomated animals treated with bicarbonate throughout the period of study. All groups of animals given SSV, with or without NaHCO3 infusion, showed a marked elevation of the concentration of urinary myoglobin (U(Mb)), plasma lactate dehydrogenase (LDH), and plasma creatine phosphokinase (CPK) throughout experimental periods. The urinary myoglobin excretion markedly increased in animals after SSV injection accompanied by NaHCO3 infusion. It can be concluded that large amounts of myoglobin present in the renal tubules in envenomated animals can precipitate, particularly under acidic conditions, resulting in increased intratubular pressure and subsequently decreased renal hemodynamics including GFR and ERBF. An infusion of NaHCO3 to render urine more alkaline could have a protective role against depression of renal function following sea snake venom administration.
机译：研究了两组静脉注射4.2 gm％NaHCO3溶液预处理的麻醉实验狗的海蛇毒（SSV）对肾功能的影响。通过肌内注射0.34mg / kg的SSV使动物致病。除了心输出量（CO）下降的趋势外，全身血流动力学无明显变化。肾小球滤过率（GFR），尿流率（V）和有效肾血浆流率（ERPF），有效肾血流率（ERBF）显着降低，而滤过率（FF）在麻醉后180分钟时显着增加。在整个实验期间，被麻醉的动物的肾分数（RF）降低，而肾血管阻力（RVR）则逐步升高。用碳酸氢钠预处理的动物在接受海蛇毒的同时，其CO，TPR MAP，HR和包装细胞体积（PCV）均无明显变化。碳酸氢钠预处理的动物在麻醉后没有显示GFR，ERPF，ERBF，RF和RVR的变化。在接受碳酸氢盐预处理的有毒动物中，尿流速度明显增加。单独进行毒化后，钠（PNa）和氯化物（PC1）的血浆浓度与对照值相比没有差异，而在毒化后180分钟，钾（PK）的血浆浓度增加。用碳酸氢盐预处理的动物显示，伴随SSV注射，UNaV，FE（NA），U（Cl）V和FE（Cl）均逐步增加。 PNa和PC1均未受影响，而给予碳酸氢盐负荷的SSV的动物的PK明显降低。在整个研究过程中，用碳酸氢盐处理的被麻醉动物的UKV和FEK逐步增加。在整个实验期间，所有接受SSV或不添加NaHCO3的动物均显示尿肌红蛋白（U（Mb）），血浆乳酸脱氢酶（LDH）和血浆肌酸磷酸激酶（CPK）浓度显着升高。在注射SSV并伴有NaHCO3注入后，动物的尿肌红蛋白排泄显着增加。可以得出结论，在有毒动物的肾小管中存在大量的肌红蛋白会沉淀，尤其是在酸性条件下，会导致肾小管内压力升高，进而降低包括GFR和ERBF在内的肾脏血液动力学。输注NaHCO3使尿液更具碱性，在服用海蛇毒后可具有防止肾功能下降的保护作用。

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