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首页> 外文期刊>Journal of Nature Conservation >STUDIES ON SUSCEPTIBILITY AND MINIMUM INHIBITORY CONCENTRATION OF CEFTRIAXONE AND VANCOMYCIN ALONE AND IN COMBINATION IN BACILLUS SUBTILIS, ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA.
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STUDIES ON SUSCEPTIBILITY AND MINIMUM INHIBITORY CONCENTRATION OF CEFTRIAXONE AND VANCOMYCIN ALONE AND IN COMBINATION IN BACILLUS SUBTILIS, ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA.

机译：芽孢杆菌，大肠埃希氏菌和铜绿假单胞菌对头孢曲松和万古霉素单独和联合使用的敏感性和最低抑菌浓度的研究。

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摘要

The present investigation was carried out to study susceptibility and Minimum Inhibitory Concentration (MIC) of Ceftriaxone (C) and Vancomycin (V) individually and Fixed Dose combination (FDC) of Ceftriaxone Vancomycin (CV) in Escherichia coll, Pseudomonas aeruginosa and Bacillus subtilis. Chemical Vector Mediated Compatibility (CMVC) was obtained at the R & D Centre for CV and ratio of C and V was taken as 2:1. The MIC was determined by broth microdilution method as per the standard National Committee for Clinical Laboratory Standards using the agar dilution procedure that conforms to the guidelines. The Bacterial Susceptibility Test was performed for each of the specified bacteria by determining the lysis zone for the combination and each antibiotic individually. The lytic zone measurement was more in combination than in individual antibiotics in all the bacterial plates under study. No growth was observed at higher concentration of 128, 64, 32, 16, 8 and 4 mu g/ml C, V and CV for all the organisms . The study suggested that the MIC was least for all the three organisms for CV as compared to that of C or V alone.
机译：本研究旨在研究头孢曲松（C）和万古霉素（V）的药敏性和最低抑菌浓度（MIC）和头孢曲松万古霉素（CV）的固定剂量组合（FDC）在大肠杆菌，铜绿假单胞菌和枯草芽孢杆菌中的敏感性。在CV的研发中心获得了化学载体介导的兼容性（CMVC），并且C与V的比例为2：1。根据国家临床实验室标准委员会的标准，通过肉汤微量稀释法使用符合指导原则的琼脂稀释程序确定MIC。通过确定组合和每种抗生素的裂解区域，对每种指定细菌进行了细菌药敏试验。在所有研究的细菌培养皿中，裂解区的测量结果要比单个抗生素的测量结果更多。对于所有生物，在128、64、32、16、8和4μg / ml C，V和CV的较高浓度下均未观察到生长。研究表明，与单独使用C或V的微生物相比，使用CV的三种微生物的MIC最低。

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