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首页> 外文期刊>Journal of near infrared spectroscopy >Feasibility study of diffuse reflectance and transmittance near infrared spectroscopy for rapid analysis of ascorbic acid concentration in bilayer tablets using a high-speed polychromator-type spectrometer
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Feasibility study of diffuse reflectance and transmittance near infrared spectroscopy for rapid analysis of ascorbic acid concentration in bilayer tablets using a high-speed polychromator-type spectrometer

机译：高速多色仪型光谱仪用于漫反射和透射率近红外光谱分析双层片剂中抗坏血酸浓度的可行性研究

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The feasibility of real-time release testing of bilayer tablets was investigated using near infrared (NIR) spectroscopy. The newly developed polychromator-type NIR spectrometer was used to compare the diffuse reflectance (DR) and transmittance (Tr) NIR spectroscopic techniques. This spectrometer not only performs highly sensitive NIR measurements but also yields the NIR spectra of an intact tablet on a millisecond (ms) timescale; i.e. 500 ms for the DR-NIR measurements and 400 ms for the Tr-NIR measurements. The bilayer tablets were prepared with the first layer comprising 0-10% ascorbic acid (AsA), 20% corn starch, 5% talc, 30% microcrystalline cellulose and 45-35% lactose, and the second layer comprising 20% corn starch, 5% talc, 30% microcrystalline cellulose and 45% lactose; their DR-and Tr-NIR spectra were acquired from both sides of the tablet. With these spectra, the feasibility of DR- and Tr-NIR spectroscopy for the quantitative analysis of AsA in the bilayer tablets was compared. The DR- and Tr-NIR spectra of the bilayer tablets and their second-derivative spectra were studied. The AsA bands were not identified in the DR- and Tr-NIR spectra. However, the AsA bands at 995nm and 1458 nm were observed in the second-derivative spectra. All the developed regression models predicted the AsA concentration, and regression vectors indicated that the prediction was based on the AsA bands. In addition, the model using the Tr-NiR spectra was able to predict the AsA concentration, even when the bilayer tablet was flipped.
机译：使用近红外（NIR）光谱技术研究了双层片剂实时释放测试的可行性。新开发的多色仪型近红外光谱仪用于比较漫反射率（DR）和透射率（Tr）近红外光谱技术。这种光谱仪不仅可以执行高灵敏度的NIR测量，而且还可以在毫秒（ms）的时间范围内生成完整药片的NIR光谱。即DR-NIR测量为500毫秒，Tr-NIR测量为400毫秒。制备双层片剂，其中第一层包含0-10％的抗坏血酸（AsA），20％玉米淀粉，5％滑石粉，30％微晶纤维素和45-35％乳糖，第二层包含20％玉米淀粉， 5％滑石粉，30％微晶纤维素和45％乳糖;他们的DR和Tr-NIR光谱是从平板电脑的两侧获取的。使用这些光谱，比较了DR-和Tr-NIR光谱用于双层片剂中AsA定量分析的可行性。研究了双层片剂的DR-和Tr-NIR光谱及其二阶导数光谱。在DR和Tr-NIR光谱中未识别出AsA谱带。但是，在二阶导数光谱中观察到了995nm和1458 nm的AsA谱带。所有已开发的回归模型都预测了AsA浓度，回归向量表明该预测基于AsA谱带。此外，即使将双层片剂翻转，使用Tr-NiR光谱的模型也能够预测AsA浓度。

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