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首页> 外文期刊>Journal of neurotrauma >Diverse Effects of Hypothermia Therapy in Patients with Severe Traumatic Brain Injury Based on the Computed Tomography Classification of the Traumatic Coma Data Bank
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Diverse Effects of Hypothermia Therapy in Patients with Severe Traumatic Brain Injury Based on the Computed Tomography Classification of the Traumatic Coma Data Bank

机译：基于创伤性昏迷数据库的计算机体层摄影术分类，低温疗法对严重颅脑损伤患者的不同作用

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摘要

A multicenter randomized controlled trial of patients with severe traumatic brain injury who received therapeutic hypothermia or fever control was performed from 2002 to 2008 in Japan (BHYPO). There was no difference in the therapeutic effect on traumatic brain injury between the two groups. The efficacy of hypothermia treatment and the objective of the treatment were reexamined based on a secondary analysis of the BHYPO trial in 135 patients (88 treated with therapeutic hypothermia and 47 with fever control). This analysis was performed to examine clinical outcomes according to the CT classification of the Traumatic Coma Data Bank on admission. Clinical outcomes were evaluated with the Glasgow Outcome Scale and mortality at 6 months after injury. Good recovery and moderate disability were defined as favorable outcomes. Favorable outcomes in young patients (<= 50 years old) with evacuated mass lesions significantly increased from 33.3% with fever control to 77.8% with therapeutic hypothermia. Patients with diffuse injury III who were treated with therapeutic hypothermia, however, had significantly higher mortality than patients treated with fever control. It was difficult to control intracranial pressure with hypothermia for patients with diffuse injury III, but hypothermia was effective for young patients with an evacuated mass lesion.
机译：日本（BHYPO）于2002年至2008年进行了一项多中心随机对照试验，该试验针对接受治疗性低温或发烧控制的严重颅脑损伤患者进行。两组对脑外伤的治疗效果无差异。根据135例BHYPO试验的次要分析（88例接受治疗性低温治疗，47例接受发烧控制），重新检查了低温治疗的疗效和治疗目的。根据入院时创伤性昏迷数据库的CT分类进行了此项分析以检查临床结局。使用格拉斯哥结果量表和受伤后6个月的死亡率评估临床结局。良好的康复和中度残疾被定义为良好的预后。疏散性肿块的年轻患者（<= 50岁）的良好结局从控制发烧的33.3％显着提高到治疗性体温过低的77.8％。但是，接受治疗性低温治疗的弥漫性损伤III患者的死亡率显着高于发烧对照患者。对于弥散性损伤III患者，很难通过体温过低控制颅内压，但是体温过低对于疏散性大块病变的年轻患者有效。

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