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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Transformations of glassy indomethacin induced by ball-milling
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Transformations of glassy indomethacin induced by ball-milling

机译：球磨诱导玻璃状消炎痛的转化

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摘要

pharmaceutical compound was performed at room temperature. The effects of the milling intensity and duration on the physical state of the glass were investigated by X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). Depending on the milling parameters, either we observed crystallization under milling or a modification of the physical state of the glass itself. The results are confronted with previous investigations of the effects of both the cooling rate of the melt and the physical ageing of the glass. The possibilities for milling to change the configurational state of the glassy state and the local molecular organization are discussed. (c) 2006 Elsevier B.V. All rights reserved.
机译：药物化合物在室温下进行。通过X射线粉末衍射（XRPD）和差示扫描量热法（DSC）研究了研磨强度和研磨时间对玻璃物理状态的影响。取决于研磨参数，我们观察到研磨下的结晶或玻璃本身物理状态的改变。结果与先前对熔体冷却速率和玻璃物理老化的影响的研究相面对。讨论了研磨以改变玻璃态的构型状态和局部分子组织的可能性。 （c）2006 Elsevier B.V.保留所有权利。

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