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Functionalization and bioactivity in vitro of mesoporous bioactive glasses

机译:中孔生物活性玻璃的体外功能化和生物活性

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摘要

Amino and carboxylic groups functionalized mesoporous bioactive glasses (denoted as N-MBGs and C-MBGs, respectively) were successfully synthesized through a post-grafting process and characterized by XRD, N-2 sorption, TEM, FT-IR and TG techniques. Their in vitro bioactivity and degradation behavior were investigated in simulated body fluid and examined by various techniques. The results demonstrate that the bioactivity of all the samples and the morphology of carbonated hydroxyapatite were affected remarkably by the introduction of functional groups. Spherical carbonated hydroxyapatite particles were observed grown on the N-MBGs surfaces after soaking in simulated body fluid for 8 h, which is different from the rod-like carbonated hydroxyapatite grown on conventional mesoporous bioactive glasses. While for C-MBGs, the nucleation and growth rate of carbonated hydroxyapatite was decreased at increased contents of carboxylic groups. (c) 2008 Elsevier B.V. All rights reserved.
机译:通过接枝后工艺成功合成了具有氨基和羧基功能的介孔生物活性玻璃(分别称为N-MBG和C-MBG),并通过XRD,N-2吸附,TEM,FT-IR和TG技术对其进行了表征。在模拟体液中研究了它们的体外生物活性和降解行为,并通过各种技术对其进行了检查。结果表明,所有样品的生物活性和碳酸羟基磷灰石的形态都受到官能团的引入的显着影响。浸泡在模拟体液中8 h后,在N-MBGs表面观察到球形碳酸羟基磷灰石颗粒的生长,这与在常规介孔生物活性玻璃上生长的棒状碳酸羟基磷灰石不同。而对于C-MBG,随着羧基含量的增加,碳酸羟基磷灰石的成核和生长速率降低。 (c)2008 Elsevier B.V.保留所有权利。

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