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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Effect of surface functionalization of silica aerogel on their adsorptive and release properties
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Effect of surface functionalization of silica aerogel on their adsorptive and release properties

机译：二氧化硅气凝胶的表面功能化对其吸附和释放性能的影响

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Due to their high surface area, open pore structure and biocompatibility silica aerogels were shown to be a promising candidate for drug delivery systems. This work aims to show the possibility of functionalizing silica aerogel with functional groups to tailor their surface properties for specific applications. Amino groups were taken as a model functional group. Ketoprofen loading on aerogels was taken as a drug delivery application. Two different functionalization approaches were followed: pretreatment of the gel before the drying step, and a post treatment of the dried aerogels. The amino-functionalized aerogels obtained by both methods were characterized by CHN and BET analysis, as well as UV-spectroscopy. It has been shown that the functionalized silica aerogels obtained by these methods maintain similar structural properties as the original ones. For the first time transparent amino-modified aerogels with a surface area up to 1000 m~2/g were obtained. These aerogels were loaded with the drug ketoprofen by adsorption from supercritical CO_2. The loading was shown to be a function of the concentration of the amino groups on the aerogel surface, due to their strong adsorptive interactions with the acidic group of ketoprofen. The release rate of ketoprofen from the loaded amino-modified aerogels was close to that of original ones. Thus, aerogels functionalization opens the possibility to design a high capacity carrier for a specific active substance, as well as to control the release of that substance in the corresponding media.
机译：由于其高表面积，开孔结构和生物相容性二氧化硅气凝胶被证明是药物输送系统的有前途的候选者。这项工作旨在表明用官能团对二氧化硅气凝胶进行官能化以针对特定应用定制其表面性能的可能性。将氨基基团作为模型功能基团。酮洛芬在气凝胶上的负载量被用作药物递送应用。遵循两种不同的功能化方法：在干燥步骤之前对凝胶进行预处理，以及对干燥的气凝胶进行后处理。通过CHN和BET分析以及紫外光谱对通过这两种方法获得的氨基官能化气凝胶进行了表征。已经表明，通过这些方法获得的官能化二氧化硅气凝胶保持与原始类似的结构性质。首次获得了表面积高达1000 m〜2 / g的透明氨基改性气凝胶。这些气凝胶通过从超临界CO_2吸附而载有药物酮洛芬。由于其与酮洛芬的酸性基团的强吸附性相互作用，显示其负载是气凝胶表面上氨基基团浓度的函数。负载的氨基修饰气凝胶中酮洛芬的释放速率与原始释放速率接近。因此，气凝胶功能化为设计特定活性物质的高容量载体以及控制该物质在相应介质中的释放提供了可能性。

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