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首页> 外文期刊>Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry >Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity.
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Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity.

机译：金雀异黄素是一种来自大豆的天然植物雌激素，可减轻小鼠慢性收缩坐骨神经损伤后的神经性疼痛：抗炎和抗氧化活性。

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There is great interest in soy isoflavones as alternatives to endogenous estrogens not only in hormonal pathologies, but also in inflammatory, neurodegenerative diseases, and pain. We investigated the effect of the isoflavone genistein on neuropathic pain. Genistein binds estrogen receptors (ER) with higher affinity for the ERbeta particularly expressed in neuronal and immune cells. Neuropathy was induced in mice by means of chronic sciatic nerve constriction, and the subcutaneous administration of genistein from the third day after the lesion reversed pain hypersensitivity in a time- and dose-dependent manner. This effect may have been due to the activation of classical nuclear receptor and/or anti-oxidant, anti-inflammatory, and immunomodulating properties of genistein. The fact that a specific ERbeta antagonist prevented both its anti-allodynic and anti-hyperalgesic action, whereas a specific ERalpha antagonist was ineffective and a non-selective ER antagonist only reversed the anti-allodynic effect, suggests the involvement of ERbeta. Antioxidant effects are also involved as the anti-nociceptive dose reversed the increase in reactive oxygen species and malondialdehyde in injured paw tissues, and increased the activity of anti-oxidant enzymes. The phytoestrogen had immunomodulatory and anti-inflammatory activities as it reduced peripheral and central nuclear factor-kappaB, nitric oxide system and pro-inflammatory cytokine over-activation. Taken together, our results suggest that genistein could ameliorate painful neuropathy by multiple mechanisms.
机译：大豆异黄酮作为内源性雌激素的替代品，不仅在激素病理方面，而且在炎性，神经退行性疾病和疼痛中也引起了极大的兴趣。我们调查了异黄酮金雀异黄素对神经性疼痛的影响。金雀异黄素以更高的亲和力结合雌激素受体（ER），特别是在神经元和免疫细胞中表达的ERbeta。通过慢性坐骨神经收缩在小鼠中引起神经病，并且从损伤后第三天开始皮下注射染料木黄酮可以以时间和剂量依赖性方式逆转疼痛超敏反应。这种作用可能是由于经典染料木黄酮的激活和/或经典的核受体和/或抗氧化剂，抗炎和免疫调节特性所致。特定的ERbeta拮抗剂同时阻止其抗痛觉过敏和抗痛觉过敏作用，而特定的ERalpha拮抗剂无效，而非选择性的ER拮抗剂只能逆转抗痛觉过敏作用，这一事实表明ERbeta的参与。由于抗伤害性剂量使受伤的爪组织中活性氧和丙二醛的含量增加逆转，并增加了抗氧化酶的活性，因此也涉及抗氧化作用。植物雌激素具有免疫调节和抗炎活性，因为它减少了外周和中枢核因子-κB，一氧化氮系统和促炎性细胞因子的过度活化。两者合计，我们的结果表明，染料木黄酮可以通过多种机制缓解疼痛性神经病。

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