Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures.

Li Y; Meyer EM; Walker DW; Millard WJ; He YJ; King MA

首页> 外文期刊>Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry >Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures.

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Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures.

机译：在主要大鼠海马神经元培养物中，Alpha7烟碱样受体的活化抑制乙醇诱导的线粒体功能障碍，细胞色素C释放和神经毒性。

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Primary hippocampal neuronal cultures exhibited a concentration- and time-dependent loss of cells when exposed to ethanol (EtOH). EtOH-induced neurotoxicity was attenuated by 2,4-dimethoxybenzilidene anabaseine (DMXB) which selectively activates alpha7 nicotinic receptors in a concentration-dependent manner. We further investigated the mechanisms of the protective effect of DMXB on EtOH- induced neurotoxicity. We found that EtOH decreased the mitochondrial membrane potential and released cytochrome c from mitochondria at neurotoxic concentrations. DMXB (3 microm) attenuated both of these actions in a manner that was in turn blocked with the nicotinic antagonist methyllyconitine (MLA) 100 nm. Neither DMXB nor MLA alone affected these parameters. These results suggest that the neuroprotection conferred by alpha7 nicotinic receptor activation may be mediated, at least in part, through preventing the decrease in the mitochondrial membrane potential and the increase in the release of cytochrome c caused by EtOH.

机译：当暴露于乙醇（EtOH）时，原代海马神经元培养物表现出浓度和时间依赖性的细胞损失。 EtOH诱导的神经毒性被2,4-二甲氧基苯并亚基天麻碱（DMXB）减弱，后者以浓度依赖性方式选择性激活α7烟碱样受体。我们进一步研究了DMXB对EtOH诱导的神经毒性的保护作用的机制。我们发现，EtOH在神经毒性浓度下会降低线粒体膜电位，并从线粒体释放细胞色素c。 DMXB（3微米）以一种方式减弱了这两种作用，而这种方式又被100 nm的烟碱拮抗物甲基-糖耐酸（MLA）阻断。 DMXB和MLA都不会单独影响这些参数。这些结果表明，由α7烟碱样受体激活赋予的神经保护作用可以至少部分地通过防止线粒体膜电位的降低和由EtOH引起的细胞色素c的释放的增加而介导。

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《Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry》 |2002年第4期|共6页
作者
Li Y; Meyer EM; Walker DW; Millard WJ; He YJ; King MA;
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正文语种 eng
中图分类生物化学;
关键词
Neurotoxicity Syndromes; Receptors; Nicotinic; Cytochrome c; Discharge (release); 受体; 烟碱; 细胞色素C;

机译：Neurotoxicity Syndromes;Receptors;Nicotinic;Cytochrome c;Discharge (release);受体;烟碱;细胞色素C;

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1. Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures. [J] . Li Y, Meyer EM, Walker DW, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2002,第4期

机译：在主要大鼠海马神经元培养物中，Alpha7烟碱样受体的活化抑制乙醇诱导的线粒体功能障碍，细胞色素C释放和神经毒性。
2. Activation of CB1 cannabinoid receptors inhibits neurotransmitter release from identified synaptic sites in rat hippocampal cultures. [J] . Kim DJ, Thayer SA Brain research . 2000,第2期

机译：CB1大麻素受体的激活抑制了大鼠海马培养物中已确定的突触位点释放神经递质。
3. P2X(7) receptors exert a permissive role on the activation of release-enhancing presynaptic alpha7 nicotinic receptors co-existing on rat neocortex glutamatergic terminals. [J] . Patti L, Raiteri L, Grilli M, Neuropharmacology . 2006,第6期

机译：P2X（7）受体在大鼠新皮层谷氨酸能终末共存的释放增强突触前α7烟碱受体的激活中发挥作用。
4. Anesthetics modulate the release of glutamate and GABA via neuronal nicotinic acetylcholine receptors [C] . Shigeki Moriguchi, William Marszalec, Xilong Zhao, International Conference on Basic and Systemic Mechanisms of Anesthesia . 2005

机译：麻醉剂通过神经元烟碱乙酰胆碱受体调节谷氨酸和GABA的释放
5. Identification, pharmacology and anatomical localization of heteromeric neuronal nicotinic acetylcholine receptors in the rat hippocampus Effects of nicotine on nicotinic receptors expressed in rat primary cultured neurons . [D] . Lomazzo, Ermelinda. 2011

机译：大鼠海马异源神经元烟碱乙酰胆碱受体的鉴定，药理和解剖学定位烟碱对大鼠原代培养神经元表达的烟碱受体的影响。
6. TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia [O] . T.A. Hauser, A. Kucinski, K.G. Jordan, -1

机译：TC-5619：α7神经元烟碱受体选择性激动剂证明了精神分裂症的正面和阴性症状和认知功能障碍的动物模型中的疗效
7. Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures [O] . Yangxin Li, Edwin M. Meyer, Don W. Walker, 2002

机译：α7烟碱受体活化抑制乙醇诱导的线粒体功能障碍，细胞色素C释放和原代大鼠海马神经元培养物中的神经毒性

Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures.

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