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首页> 外文期刊>Journal of neuroendocrinology >Assessment of spike activity in the supraoptic nucleus.
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Assessment of spike activity in the supraoptic nucleus.

机译：评估视上核中的尖峰活动。

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Abstract Novel approaches to the characterization of coding carried by spike trains are discussed. Measuring firing frequency alone may only partially reflect spike patterning, and can only quantify changes of the most obvious kind. We have devised a method that combines probabilistic and information approaches to quantify the variability of the interspike intervals in a way that is independent of spike frequency. To illustrate the technique, the firing of an oxytocin cell and a vasopressin cell were compared before and after osmotic stimulation. A bimodal lognormal function was fitted to the interspike interval histograms. The entropy of the log interval histogram was used to measure the variability of intervals and to reflect the coding capacity of the cell per spike. A perfect metronome shows no variability in interval and thus has no greater coding capacity than is conveyed by its frequency, whereas the variability of intervals of magnocellular neurones means that their irregular activity has greater potential for coding. While the mean spike frequency increased in both the oxytocin and vasopressin cells in response to osmotic stimulation, the changes in their irregularity showed differences. Osmotic stimulation reduced the entropy of the oxytocin cell, reflecting an increase in the regularity of its spike activity. Conversely, osmotic stimulation had little effect on the entropy of the vasopressin cell. Such differences are not evident from a simple inspection of ratemeter activity. The comparison highlights the limitations of mean spike frequency as a measure of spike coding. Parameters based on the interspike intervals constitute informative measures of spike activity that allow objective comparisons to be made between the activity under different physiological conditions.
机译：摘要讨论了表征峰值序列编码的新颖方法。仅测量点火频率可能仅部分反映尖峰图形，并且只能量化最明显的变化。我们设计了一种方法，该方法结合了概率方法和信息方法，以一种独立于尖峰频率的方式来量化尖峰间隔的可变性。为了说明该技术，在渗透刺激之前和之后比较催产素细胞和加压素细胞的发射。双峰对数正态函数拟合到峰间间隔直方图。对数间隔直方图的熵用于测量间隔的可变性并反映每个尖峰的细胞编码能力。完美的节拍器在间隔上没有变化，因此没有比其频率所传递的更大的编码能力，而大细胞神经元的间隔变化意味着它们的不规则活动具有更大的编码潜力。虽然催产素和血管加压素细胞中的平均刺突频率均随着渗透刺激而增加，但其不规则性的变化却显示出差异。渗透刺激降低了催产素细胞的熵，反映出其刺突活性的规律性增加。相反，渗透刺激对加压素细胞的熵影响很小。从对速率计活动的简单检查中看不到这种差异。该比较突出了平均尖峰频率作为尖峰编码度量的局限性。基于尖峰间隔的参数构成了尖峰活动的信息量度，可以对不同生理条件下的活动进行客观比较。

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