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首页> 外文期刊>Journal of neuroendocrinology >Anxiety and stress responses in female oxytocin deficient mice.
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Anxiety and stress responses in female oxytocin deficient mice.

机译：雌性催产素缺乏症小鼠的焦虑和应激反应。

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Abstract Oxytocin is believed to attenuate the response of the hypothalamic-pituitary-adrenal axis to stress and to be anxiolytic. Stressors with a psychological component evoke both central and peripheral secretion of oxytocin in laboratory rodents. Oxytocin gene deletion mice provide a novel way to understand the role of oxytocin in stress and anxiety-related behaviours. We present our experience with female oxytocin deficient mice that were tested in an elevated plus maze (EPM), a behavioural test of anxiety, or exposed to psychogenic stressors (platform shaker or novel environment). Oxytocin-deficient mice not only displayed more anxiety-related behaviour, but also released more corticosterone after a psychogenic stressor and manifested greater stress-induced hyperthermia compared to wild-type mice. The diurnal variation of corticosterone and the response of corticosterone to corticotropin-releasing factor were not significantly different between genotypes. We also measured Fos-immunoreactive protein, an index of neuronal activation, in the medial amygdala of female mice after EPM testing. The medial amygdala is important for processing of psychogenic stress and anxiety and also contains oxytocin pathways and oxytocin receptors. The expression of Fos in the medial amygdala of mice not exposed to the EPM was not different between genotypes. Following EPM exposure, Fos expression was greater in oxytocin null compared to wild-type mice. Our findings support the hypothesis that central oxytocin is anxiolytic, and attenuates the stress response to psychogenic provocation in female mice.
机译：摘要催产素被认为可减弱下丘脑-垂体-肾上腺轴对应激的反应并具有抗焦虑作用。具有心理成分的应激源会引起实验室啮齿动物催产素的中央和周围分泌。催产素基因缺失小鼠提供了一种新的方式来了解催产素在压力和焦虑相关行为中的作用。我们介绍了我们的女性催产素缺陷型小鼠的经验，这些小鼠在高架迷宫（EPM）中进行了测试，对焦虑的行为进行了测试，或者暴露于心理压力源（平台振动台或新型环境）中。与野生型小鼠相比，催产素缺乏的小鼠不仅表现出更多的与焦虑相关的行为，而且在产生心理压力后释放出更多的皮质酮，并且表现出更大的应激诱导的体温过高。基因型之间皮质酮的日变化和皮质酮对促肾上腺皮质激素释放因子的反应无明显差异。 EPM测试后，我们还在雌性小鼠的内侧杏仁核中测量了Fos免疫反应蛋白，这是神经元激活的指数。内侧杏仁核对于处理心理压力和焦虑很重要，并且还含有催产素途径和催产素受体。在基因型之间，未暴露于EPM的小鼠内侧杏仁核中Fos的表达没有差异。与野生型小鼠相比，EPM暴露后，催产素缺失的Fos表达更高。我们的发现支持以下假设：中央催产素具有抗焦虑作用，并减轻了雌性小鼠对心理激怒的应激反应。

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