...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of neuroendocrinology >Oxytocin in brattleboro rats: Increased synthesis is contrasted by blunted intrahypothalamic release from supraoptic nucleus neurones
【24h】

Oxytocin in brattleboro rats: Increased synthesis is contrasted by blunted intrahypothalamic release from supraoptic nucleus neurones

机译：布拉特伯勒大鼠中的催产素：增加的合成与视光上核神经元的下丘脑内钝化释放相反

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adult male Brattleboro rats were used to investigate the impact of the congenital absence of vasopressin on the release pattern of oxytocin (OXT) within the hypothalamic supraoptic nucleus (SON) in response to a 10-min forced swimming session and osmotic stimulation. Both immunohistochemical and in situ hybridisation data suggest that vasopressin-deficient animals have more oxytocin-synthesising neurones in the SON than homozygous wild-type controls. Unexpectedly, both forced swimming and peripheral osmotic stimulation resulted in a blunted release profile of oxytocin within the SON of vasopressin-deficient rats compared to controls. A similar intranuclear OXT response to direct osmotic stimulation of the SON by retrodialysis with hypertonic Ringer's solution in both genotypes confirmed the capability of SON neurones to locally release oxytocin in vasopressin-deficient rats, indicating an altered processing of information originating from multisynaptic inputs rather than a deficit in release capacity. Taken together with data obtained in previous studies, the present findings provide evidence suggesting that autocrine and paracrine signalling of magnocellular neurones differs within the paraventricular nucleus and the SON. Thus, significant alterations in intra-SON oxytocin mRNA levels cannot easily be extrapolated to intranuclear release profiles and the local signal intensity of this neuropeptide after physiological stimulation.
机译：成年雄性Brattleboro大鼠用于研究先天性血管加压素的缺乏对下丘脑超视神经核（SON）内催产素（OXT）释放模式的影响，以响应10分钟的强迫游泳和渗透刺激。免疫组化和原位杂交数据均表明，与纯合野生型对照相比，缺乏加压素的动物在SON中具有更多的催产素合成神经元。出乎意料的是，与对照相比，强迫游泳和周围渗透刺激都导致催产素释放不足，使催产素在血管加压素缺乏症大鼠的SON内释放。在两种基因型中，通过高渗林格氏液的反渗析，通过直接透析刺激SON直接刺激SON的类似核内OXT反应，都证实了SON神经元在血管加压素缺乏症大鼠中局部释放催产素的能力，这表明来自多突触输入而不是来自神经突触输入的信息处理发生了变化。释放能力不足。结合以前的研究中获得的数据，本发现提供了证据，表明脑室旁核和SON内大细胞神经元的自分泌和旁分泌信号传导是不同的。因此，SON内催产素mRNA水平的显着变化不能轻易地推断为生理刺激后该神经肽的核内释放曲线和局部信号强度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号