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首页> 外文期刊>Journal of neuroendocrinology >Physiological regulation of magnocellular neurosecretory cell activity: Integration of intrinsic, local and afferent mechanisms
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Physiological regulation of magnocellular neurosecretory cell activity: Integration of intrinsic, local and afferent mechanisms

机译：大细胞神经分泌细胞活性的生理调节：内在，局部和传入机制的整合。

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摘要

The hypothalamic supraoptic and paraventricular nuclei contain magnocellular neurosecretory cells (MNCs) that project to the posterior pituitary gland where they secrete either oxytocin or vasopressin (the antidiuretic hormone) into the circulation. Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies. Although it has long been known that the activity of MNCs depends upon afferent inputs that relay information on reproductive, osmotic and cardiovascular status, it has recently become clear that activity depends critically on local regulation by glial cells, as well as intrinsic regulation by the MNCs themselves. Here, we provide an overview of recent advances in our understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin MNC activity.
机译：下丘脑的视上核和心室旁核含有投射到垂体后叶的大细胞神经分泌细胞（MNC），在这些垂体中它们分泌催产素或加压素（抗利尿激素）进入循环系统。催产素对于出生时的分娩很重要，并且对于哺乳期间的乳汁排出至关重要。加压素主要促进肾脏中水的重吸收以维持体液平衡，但也增加血管收缩。催产素和加压素分泌的概况主要由细胞体上引发的动作电位模式决定。尽管早就知道跨国公司的活动取决于传递有关生殖，渗透和心血管状态信息的传入输入，但最近已经清楚地知道，该活动主要取决于神经胶质细胞的局部调节以及跨国公司的内在调节。他们自己。在这里，我们概述了我们对内在和局部外在机制如何与传入输入结合以产生催产素和加压素MNC活性的适当生理调节的最新进展。

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